Insecticide Resistance Management in Burkina Faso and Côte d'Ivoire

Malaria Clinical Trial

— REACT  

Official title:

Insecticide Resistance Management in Burkina Faso and Côte d'Ivoire: Research on Vector Control Strategies

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT03074435
• Other study ID #: InstitutRD
• Status: Enrolling by invitation
• Phase: Phase 3
• First received: November 4, 2016
• Last updated: March 8, 2017
• Start date: April 2016
• Est. completion date: April 2019

Study information

• Verified date: March 2017
• Source: Institut de Recherche pour le Developpement
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the benefit to use 1) insecticidal paints, 2) larvicides, 3) Ivermectin for both human and domestic animals and 4) strengthened Information, Education and Communication (IEC) strategy to complement the universal coverage with LLINs through a cluster randomized trial.

Description:

Insecticidal paint comprised of two organophosphates (OPs) and an Insect Growth Regulator (IGR). This tool targets adult mosquitoes that are resistant pyrethroids to reduce vector density.

Larvicide is a new formulation of Bacillus thuringiensis israelensis that will be implemented in major permanent breeding sites with the objective to reduce vector density.

Ivermectin will be injected to domestic animals in addition to the national campaign implemented in the study area which treats the whole population. Ivermectin reduces the survival of mosquito that blood feed on treated humans and animals.

Information, Education and Communication strategy aims to increase the adherence of the population to control tools available. Strengthening the IEC aims to increase the good use of long lasting nets.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 18000
• Est. completion date: April 2019
• Est. primary completion date: October 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 6 Months to 20 Years

Eligibility

Inclusion Criteria:

• Must be an inhabitant of the villages included into the RCT

• Aged from 6month old to 20 years old

Exclusion Criteria:

• older than 20 year old

Related Conditions & MeSH terms

• Malaria

Intervention

Device:
• Insecticidal paint
Houses will be painted with insecticidal paint
• Larvicide
Larval breeding sites will be treated with larvicide

Biological:
• Ivermectin
Doses of Ivermectin will be injected to peri-domestic animals

Behavioral:
• IEC
A reinforced information, education and communication strategy will be implemented.

Locations

Country	Name	City	State
n/a

Sponsors (3)

Lead Sponsor	Collaborator
Institut de Recherche pour le Developpement	Institut de Recherche en Sciences de la Sante, Burkina Faso, Institut Pierre Richet

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Malaria incidence	Malaria cases reported in local health system	continuous monitoring during 2 years
Secondary	Entomological Inoculation Rate	Number of infectious bites/personn	Every 8 weeks during 2 years
Secondary	Malaria prevalence	% of positive blood smears among the population between 6 months to 20 years	Every 4 months during 2 years