Treating Brain Swelling in Pediatric Cerebral Malaria — TBS  

Malaria, Cerebral Clinical Trial

Official title: Treating Brain Swelling in Pediatric Cerebral Malaria

Status Completed

Clinical Trial Summary

This study evaluates the effectiveness of two interventions in Malawian children with cerebral malaria at high risk of death. One-third of the participants will receive treatment as usual, one-third will receive treatment as usual and be placed on a mechanical ventilator, and one-third will receive treatment as usual plus intravenous hypertonic saline.

Clinical Trial Description

An important mechanism of death in children with cerebral malaria is diffuse cerebral swelling, cerebral herniation, compression of the brainstem respiratory center, and respiratory arrest. In those who survive their illness without specific interventions, reversal of diffuse cerebral swelling is rapid.

Mechanical ventilation may help to preserve life while diffuse brain swelling diminishes. Intravenous hypertonic saline may work as an osmotic diuretic, directly decreasing brain swelling. ;

Related Conditions & MeSH terms

• Brain Edema
• Malaria
• Malaria, Cerebral

• NCT number: NCT03300648
• Study type: Interventional
• Source: Michigan State University
• Status: Completed
• Phase: Phase 3
• Start date: January 8, 2018
• Completion date: December 31, 2023