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Clinical Trial Summary

This study evaluates the effectiveness of two interventions in Malawian children with cerebral malaria at high risk of death. One-third of the participants will receive treatment as usual, one-third will receive treatment as usual and be placed on a mechanical ventilator, and one-third will receive treatment as usual plus intravenous hypertonic saline.


Clinical Trial Description

An important mechanism of death in children with cerebral malaria is diffuse cerebral swelling, cerebral herniation, compression of the brainstem respiratory center, and respiratory arrest. In those who survive their illness without specific interventions, reversal of diffuse cerebral swelling is rapid. Mechanical ventilation may help to preserve life while diffuse brain swelling diminishes. Intravenous hypertonic saline may work as an osmotic diuretic, directly decreasing brain swelling. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03300648
Study type Interventional
Source Michigan State University
Contact
Status Completed
Phase Phase 3
Start date January 8, 2018
Completion date December 31, 2023

See also
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Completed NCT00658450 - Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria N/A
Recruiting NCT05478720 - DON in Pediatric Cerebral Malaria Phase 1/Phase 2
Completed NCT00292929 - Study of the Safety of Intravenous Artesunate Phase 1