Lymphoma Clinical Trial
Official title:
PET-based Evaluation of Chemotherapy-induced Brain Damage in Lymphoma Patients -Implication in the Evaluation of Neuro-cognitive Function Alteration (LYMCOTEP)
Positron emission tomography (PET) with 18-fluoro-deoxy-glucose (PET-FDG) is emerging as a promising approach for detecting brain lesions in dementia, among which Alzheimer's disease has been the most widely studied.
Alteration of neuro-cognitive function induced by chemotherapy has been extensively
documented in breast carcinoma patients. These modifications consist in the decrease of
memory, intellectual capacity, speed analysis, and represent a real limitation for patients,
sometimes durable. Aggressive lymphomas (diffuse large B cell lymphomas/DLBCL) represent a
common disease, the standard being
Rituximab-Cyclophosphamide-Doxorubicine-Vincristine-Prednisone (RCHOP) regiment which
contains, as for breast cancer patients, anthracyclines. However, very little is known about
the incidence and severity of cognitive function alteration in these patients. The
occurrence of such complications should also be facilitated because of frail cognitive
states due to age and co-morbidity. Cognitive function alteration is usually measured by
neuropsychological tests (NPT) which are easy to handle and sensitive, but could lack
specificity, in the context of general degradation which is often observed in hematological
patients.
Positron emission tomography with 18-fluoro-deoxy-glucose (PET-FDG) is emerging as a
promising approach for detecting brain lesions in dementia, among which Alzheimer's disease
has been the most widely studied. In our center, the investigators have already described
glucidic hypometabolism in several brain territories associated with Alzheimer's disease and
other dementia. Moreover, uptake quantification and topography are useful markers for
determining the type of the disease and progression. PET-FDG received very little attention
for the detection of chemotherapy-induced brain damages.
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Intervention Model: Single Group Assignment, Masking: Open Label
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