Lymphoma Clinical Trial
Official title:
CD34+Stem Cell Selection for Patients Receiving Partially Matched Family or Matched Unrelated Adult Donor Allogeneic Stem Cell Transplantations for Malignant and Non-Malignant Disease
CD34+ stem cell selection in children, adolescents and young adults receiving partially matched family donor or matched unrelated adult donor allogeneic bone marrow or peripheral blood stem cell transplant will be safe and well tolerated and be associated with a low incidence of serious (Grade III/IV) acute and chronic graft versus host disease (GVHD).
The selection of CD34+ cells is associated with the simultaneous depletion of T cells that
are responsible for severe acute and chronic graft versus host disease (GVHD). Successful
engraftment is reported in adult patients with malignant and non-malignant disease who
received CD34+ selected stem cells from HLA-matched or mismatched mobilized peripheral blood
(PBSC) or bone marrow.
Study Design:
Selected patients defined in the eligibility criteria will enrolled on this study. Patients
will receive one of either full intensity or reduced intensity regimen based on the patient's
disease status, organ function and performance and determined by the PI and will have
peripheral blood undergo CD34 selection.
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