Lymphoma Clinical Trial
Official title:
Cellular Infusions in Patients With Recurrent or Persistent Hematologic Malignancies After Allogeneic Stem Cell Transplant
RATIONALE: Giving an infusion of donor lymphocytes may be able to kill cancer cells in
patients with hematologic cancer that has come back after a donor stem cell transplant.
PURPOSE: This clinical trial is studying how well donor lymphocyte infusion works in treating
patients with recurrent or persistent hematologic cancer after donor stem cell transplant.
OBJECTIVES:
Primary
- Determine if the complete response rate exceeds 10% in patients with recurrent or
persistent hematologic malignancies treated with donor lymphocyte infusion.
Secondary
- Estimate the complete response rate in these patients.
- Assess the toxicity of donor lymphocyte infusion in these patients.
OUTLINE: Patients receive up to four donor lymphocyte infusions at least 1 month apart in the
absence of disease progression, unacceptable toxicity, or uncontrolled graft-versus-host
disease.
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