Lymphoma Clinical Trial
Official title:
A Non-Myeloablative Conditioning Regimen With Peri-Transplant Rituximab and the Transplantation of Hematopoietic Stem Cells From HLA-Compatible Related or Unrelated Donors in Patients With B Cell Lymphoid Malignancies
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor stem
cell transplant helps stop the growth of cancer cells. It also helps stop the patient's
immune system from rejecting the donor's stem cells. Also, monoclonal antibodies, such as
rituximab, can find cancer cells and either kill them or deliver cancer-killing substances to
them without harming normal cells. The donated stem cells may replace the patient's immune
cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the
transplanted cells from a donor can also make an immune response against the body's normal
cells. Giving rituximab before transplant and cyclosporine and mycophenolate mofetil after
transplant may stop this from happening.
PURPOSE: This phase II trial is studying the side effects and how well giving chemotherapy
and radiation therapy together with rituximab and donor stem cell transplant works in
treating patients with B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia.
n/a
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