Lymphoma Clinical Trial
Official title:
Thalidomide in Indolent Non-Hodgkin's Lymphoma: A Feasibility Study
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor.
PURPOSE: Phase I trial to determine the effectiveness of thalidomide in treating patients
who have asymptomatic, indolent non-Hodgkin's lymphoma or chronic lymphocytic leukemia.
OBJECTIVES:
- Determine the feasibility, in terms of toxicity and patient compliance, of thalidomide
in patients with asymptomatic, indolent non-Hodgkin's lymphoma or chronic lymphocytic
leukemia.
- Determine the event-free and progression-free survival of patients treated with this
drug.
- Determine disease response and time to next treatment in patients treated with this
drug.
- Determine the quality of life of patients treated with this drug.
OUTLINE: Patients receive oral thalidomide once daily. Treatment continues for 18 months in
the absence of disease progression or unacceptable toxicity.
Quality of life is assessed at baseline, monthly during study, and at the end of the study.
PROJECTED ACCRUAL: A total of 30-36 patients will be accrued for this study within 2 years.
;
Masking: Open Label, Primary Purpose: Treatment
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