Lymphoma Clinical Trial
Official title:
A Pilot Study Of FR901228, Or Depsipeptide (NSC #630176) For Adult Patients With Advanced Hematologic Cancers
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of FR901228 in treating patients who have
myelodysplastic syndrome, acute myeloid leukemia, or non-Hodgkin's lymphoma.
OBJECTIVES:
- Determine the pattern of adverse clinical experience in patients with myelodysplastic
syndrome, acute myeloid leukemia, or intermediate-grade or follicular non-Hodgkin's
lymphoma treated with FR901228 (depsipeptide).
- Determine the disease response in patients treated with this drug.
- Determine the pharmacokinetic and pharmacodynamic correlates of this drug, including
measurement of serum plasma levels, H3 and H4 acetylation, apoptosis induction,
differentiation, and multidrug-resistant (MDR) phenotype expression in these patients.
OUTLINE: Patients receive FR901228 (depsipeptide) IV over 4 hours on days 1 and 5. Courses
repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Patients are followed monthly.
PROJECTED ACCRUAL: A total of 12 patients will be accrued for this study within 1 year.
;
Primary Purpose: Treatment
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