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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05898477
Other study ID # IRB-300010383
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 1, 2023
Est. completion date July 2026

Study information

Verified date June 2024
Source University of Alabama at Birmingham
Contact Gaurav Goyal, MD
Phone 205-934-1816
Email ggoyal@uabmc.edu
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of the study is to describe Hemophagocytic lymphohistiocytosis (HLH) in patients with lymphoma to identify possible therapeutic strategies to improve overall survival of the patients with lymphoma associated hemophagocytic lymphohistiocytosis.


Description:

Retrospective, multi-institutional study focused on describing the clinical features, laboratory parameters, treatments, and outcomes among individuals presenting with HLH in the setting of a lymphoma


Recruitment information / eligibility

Status Recruiting
Enrollment 2000
Est. completion date July 2026
Est. primary completion date January 2026
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Patients with lymphoma that are fulfilling at least one of the following: A. Meeting 5 of 8 HLH-2004 diagnostic criteria OR B. Are OHI index positive (sCD25>3,900 U/mL and ferritin>1,000 ng/mL) Exclusion Criteria: - Patients developing HLH> 1 month after lymphoma diagnosis (for aggressive lymphomas) - Patients with incomplete treatment and response documentation

Study Design


Related Conditions & MeSH terms

  • Hemophagocytic Lymphohistiocytoses
  • Lymphohistiocytosis, Hemophagocytic
  • Lymphoma

Locations

Country Name City State
United States University of Alabama at Birmingham Birmingham Alabama

Sponsors (1)

Lead Sponsor Collaborator
University of Alabama at Birmingham

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary To determine the factors predicting 180 days overall survival of patients with cancer that are HLH-2004/OHI+ The investigators will gather data on different treatments received, time to treatment, and other factors and determine which is associated with survival. The participant's survival would be assessed at 180 days from the malignancy diagnosis
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