Lymphoma Clinical Trial
Official title:
Transplantation Using Umbilical Cord And Placental Blood
RATIONALE: Umbilical cord blood or placental blood transplantation may be able to replace
immune cells that were destroyed by the chemotherapy or radiation therapy that was used to
kill cancer cells.
PURPOSE: Phase II trial to study the effectiveness of umbilical cord blood and placental
blood transplantation in treating patients who have hematologic cancer or aplastic anemia.
OBJECTIVES:
- Determine the response rate of patients with chronic myeloid leukemia, acute leukemia,
lymphoma, myeloma, myelodysplasia, aplastic anemia, Fanconi's anemia, histiocytosis,
hereditary immunodeficiency, or storage disorder treated with allogeneic umbilical cord
and placental blood transplantation.
- Determine the toxicity of this regimen in these patients.
- Determine survival in these patients treated with this regimen.
- Determine the incidence of graft-versus-host disease in these patients treated with
this regimen.
OUTLINE: Patients receive a standard preparative regimen for their disease. Following the
preparative regimen patients undergo umbilical cord blood stem cell transplantation on day
0.
Patients are followed every 1-2 weeks for 6 months.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study within 4-5 years.
;
Primary Purpose: Treatment
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