| Eligibility |
Inclusion Criteria:
Patients must meet all of the following criteria to be eligible:
- Histologically proven marginal zone lymphoma (splenic, nodal and extra-nodal subtypes
included). Patients with clinical and histological evidence of large-cell
transformation should be excluded from participating in this study
- Prior treatment with one or more lines rituximab or rituximab-based chemoimmunotherapy
with failure to achieve at least a partial response (PR) or documented disease
progression
- Age = 21 years of age
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- At least 1 measurable disease site on computed tomography (CT) scan that is at least
1.5cm in the longest dimension. Lesions that are not well visualized by CT may be
measured by magnetic resonance imaging (MRI) instead
- Women of childbearing potential must have a negative serum (beta-human chorionic
gonadotropin [ß-hCG]) at Screening. Women of childbearing potential are defined as
sexually mature women who have not undergone a hysterectomy or bilateral tubal
ligation or bilateral oopphorectomy or who have not been naturally postmenopausal for
> 2 years
- Women of childbearing potential and men who are sexually active must be practicing a
highly effective method of birth control during and after the study consistent with
local regulations regarding the use of birth control methods for subjects
participating in clinical trials. Men must agree to not donate sperm during and after
the study. For females, these restrictions apply for 1 month after the last dose of
study drug. For males, these restrictions apply for 3 months after the last dose of
study drug. Patient must have an indication for treatment e.g., symptoms from disease,
bulky disease (>5cm), threatened end-organ function, or cytopenias requiring
transfusion or growth factor support
- Sign (or their legally-acceptable representatives must sign) an informed consent
document indicating that they understand the purpose of and procedures required for
the study, including biomarkers, and are willing to participate in the study
- Adequate hematological and biochemical parameters within 7 days prior to enrollment as
defined below:
Haematological
- Hb =8g/dL
- Platelets =100,000/mm3 or =50,000/mm3 if bone marrow involvement independent of
transfusion support in either situation
- Absolute neutrophil count (ANC) =1000/mm3 independent of growth factor support
Biochemical
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =3 x upper limit
of normal (ULN)
- Total bilirubin =1.5 x ULN (unless elevated bilirubin is non-hepatic in origin or due
to Gilbert's syndrome)
- Serum creatinine =2 x ULN or estimate glomerular filtration rate (GFR)(Cockroft Gault)
= 40 mL/min/1.73m2
Exclusion Criteria:
Patients who meet any of the following criteria are not eligible
- Prior chemotherapy within 3 weeks, therapeutic anticancer antibodies within 4 weeks,
radio or toxin-immunoconjugates within 10 weeks, radiation therapy or other
investigational agents within 3 weeks, or major surgery within 4 weeks of first dose
of study drug
- Prior treatment with ibrutinib or other BTK inhibitors or PI3K delta inhibitors
- Concurrent enrolment in another therapeutic investigational clinical treatment study
- Prior allogeneic hematopoietic stem cell transplant. Prior autologous hematopoietic
stem cell transplant is allowed
- Vaccinated with live, attenuated vaccines within 4 weeks of enrollment
- Known central nervous system lymphoma
- History of prior malignancy, except:
- Malignancy treated with curative intent and with no known active disease present
for =3 years before enrollment
- Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
of disease
- Adequately treated cervical carcinoma in situ without evidence of disease
- History of stroke or intracranial hemorrhage within 6 months prior to enrollment
- Requires anticoagulation with warfarin or equivalent vitamin K antagonists (eg,
phenprocoumon)
- Requires treatment with strong cytochrome P450(CYP)3A4/5 inhibitors
- Clinically significant cardiovascular disease such as uncontrolled or symptomatic
arrythmias, congestive cardiac failure or myocardial infarction within 6 months of
screening, or any class 3 (moderate) or class 4 (severe) cardiac disease as defined by
the New York Heart Association Functional Classification
- Significant screening electrocardiogram (ECG) abnormalities including left bundle
branch block, 2nd degree atrioventricular (AV) block type II, 3rd degree block, or
corrected QT interval (QTc) =470 msec
- Known history of Human Immunodeficiency Virus (HIV), or active Hepatitis C or active
Hepatitis B Virus infection or any uncontrolled active systemic infection requiring
intravenous (IV) antibiotics
- Pregnant or lactating women
- Any life-threatening illness, medical condition, or organ system dysfunction which, in
the investigator's opinion, could compromise the subject's safety, interfere with the
absorption or metabolism of ibrutinib capsules, or put the study outcomes at undue
risk.
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