Lupus Nephritis Clinical Trial
Official title:
Potential of Periostin as a Tissue and Urinary Biomarker in Lupus Nephritis and IgA Nephropathy Patients
The purpose of this study is to determine the location of periostin and urine periostin level in patients with lupus nephritis and IgA nephropathy.
Total of 50 lupus nephritis and IgA nephropathy patients who met the inclusion criteria were
included in this study. The information sheet and informed consent will be obtained before
collecting the patient's data. All patients were interviewed for collecting demographic data
and laboratory testing were reviewed from patient's record. Kidney tissue and urine sample
were collected at the biopsy date from patients.Kidney tissue were stained with hematoxylin
and eosin (H&E), Masson's trichrome solution and immunohistochemistry for periostin. The
location of periostin staining in kidney tissue were assessed by renal pathologist.
The total of 50 urine samples from patients and 50 urine samples from healthy controls were
measured for periostin level by enzyme-linked immunosorbent assay. The Mann-Whitney rank-sum
test was used for comparing urine periostin level between patients and healthy controls and
also other variables between patients with urine periostin detection and without urine
periostin detection. Spearman correlation coefficients were used test correlations between
urine periostin level in patients and other variables. Receiver operating characteristic
curves was generated to calculate the area under the curve and find the best cutoff value of
urine periostin level for distinguishing patients from healthy controls. P-values < 0.05
were considered statistically significant.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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