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Lung Neoplasms clinical trials

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NCT ID: NCT03705546 Active, not recruiting - Lung Neoplasms Clinical Trials

The Impact of Physical Activity on the Postoperative Symptoms, Complications, and Quality of Life Among Lung Cancer

Start date: March 4, 2016
Phase:
Study type: Observational

The purpose of this study is to examine the impact of physical activity on the postoperative symptoms, complication, and quality of life.

NCT ID: NCT03704870 Completed - Lung Cancer Clinical Trials

Outcomes Following Omission of Daily Routine Chest Radiographs Following Pulmonary Resection

Start date: January 26, 2018
Phase: Phase 2
Study type: Interventional

Currently, it is the standard of care practice to perform daily routine CXR when a chest tube is in situ following pulmonary resection. However, previous research as well as experience of thoracic surgeons suggested this kind of management has poor diagnostic and therapeutic value. Eliminating daily routine CXR for adult patients having undergone pulmonary surgery might decrease the frequency of radiation exposure and hospitalization costs per patient without increasing reintervention rates, length of hospital stays, readmission rates or any adverse events.

NCT ID: NCT03704688 Completed - Clinical trials for Non Small Cell Lung Cancer

Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer

Start date: October 9, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety of the combination of ponatinib and trametinib as well as the most appropriate dosages of the combination.

NCT ID: NCT03703596 Not yet recruiting - Lung Cancer Clinical Trials

Anlotinib Versus Docetaxel as the Second-line Treatment in EGFR Wild Type Patients With Advanced NSCLC

Start date: October 16, 2018
Phase: Phase 2
Study type: Interventional

This study is conducted to explore the safety and efficacy of anlotinib, a tyrosine kinase inhibitors of Vascular Endothelial Growth Factor Receptor 2(VEGFR)、FGFR(Fibroblast Growth Factor Receptor), Platelet-derived growth factor Receptor(PDGFR) and c-kit, vs docetaxel in advanced Non-squamous Non-small cell lung cancer harbouring wild-type epidermal growth factor receptor (EGFR) .

NCT ID: NCT03703297 Active, not recruiting - Clinical trials for Small Cell Lung Cancer

Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy

ADRIATIC
Start date: September 27, 2018
Phase: Phase 3
Study type: Interventional

This is a Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation Treatment for Patients with LS-SCLC Who Have Not Progressed Following Concurrent Chemoradiation Therapy

NCT ID: NCT03700437 Completed - Clinical trials for Non-small Cell Lung Cancer

Fasting-mimicking Diet With Chemo-immunotherapy in Non-small Cell Lung Cancer (NSCLC)

Start date: November 2, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to learn the effects of fasting on cancer cells while you get maintenance treatment.

NCT ID: NCT03699956 Terminated - Clinical trials for Carcinoma, Small Cell Lung

RRx-001 Sequentially With a Platinum Doublet or a Platinum Doublet in Third-Line or Beyond in Patients With Small Cell Lung Cancer

REPLATINUM
Start date: December 24, 2018
Phase: Phase 3
Study type: Interventional

This Phase 3 study aims to find out whether RRx-001 + platinum chemotherapy is more effective than platinum chemotherapy alone in 3rd line or beyond small cell cancer.

NCT ID: NCT03699033 Withdrawn - Clinical trials for Non Small Cell Lung Cancer

Hypofractionated Radiotherapy With Carboplatin and Paclitaxel in Non-Small Cell Lung Cancer

Start date: October 1, 2018
Phase: Phase 2
Study type: Interventional

Single center, single arm, Phase II study designed to evaluate the feasibility of hypofractionated IMRT to 62.5 Gy in 25 fractions (2.5 Gy/fraction) with 4D PET/CT-based radiation treatment planning and concurrent carboplatin and paclitaxel in Stage IIIA or Stage IIIB NSCLC subjects.

NCT ID: NCT03696212 Terminated - Clinical trials for Non-small Cell Lung Cancer Adenocarcinoma

Grapiprant (ARY-007) and Pembrolizumab in Patients With Advanced or Metastatic Post-PD-1/L1 NSCLC Adenocarcinoma

Start date: January 8, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This study will be conducted in adult participants diagnosed with NSCLC who have been previously treated for a minimum of 12 weeks with any PD-1 or PD-L1 checkpoint inhibitor. This is a phase 1b/2, multi-center, open label study designed to assess safety and tolerability of grapiprant in combination with pembrolizumab, to determine the recommended phase 2 dose (RP2D) with pembrolizumab, and to evaluate disease response with grapiprant based on investigator assessments. Pharmacokinetics, pharmacodynamics and response biomarkers will also be assessed.

NCT ID: NCT03694054 Completed - Lung Cancer Clinical Trials

Care Coordination in Oncology, Quality Among Patients With Lung Cancer and Their Caregivers

Start date: June 4, 2018
Phase: N/A
Study type: Interventional

The Oncology Care Coordination study is designed to evaluate use of a care coordination tool for lung cancer patients and their caregiver on quality of care and performance outcomes. Eligible patients need to be receiving treatment at Geisinger. Participation in the study involves completion of surveys, permission to review information from the patient's electronic health record, and for some enrollment in the care coordination tool called Harmonized Care. Geisinger oncology care providers who have patients enrolled the study will be invited for interviews.