The Effect of Sevoflurane & Desflurane on Clara Cell Protein on the Lung

Status Completed

Clinical Trial Summary

Inhalation anesthesia; It means that the anesthetic drugs taken by the respiratory tract pass into the blood through the lung alveoli, reach the brain tissue, and create an anesthetic effect according to the density in the brain tissue. All inhalation anesthetics affect organ functions to varying degrees. Clara cell has been shown to have cell regeneration, immunomodulatory, anti-inflammatory and antioxidant activity in the bronchial epithelium. It is also thought that some substances accumulated in the respiratory system participate in the detoxification. Clara cell protein acts as a protein marker that indicates the severity of airway injuries after exposure to irritants. In this study, we planned to investigate the effect of inhalation anesthetics on Clara cell protein in liver transplant donors who will undergo hepatectomy surgery.

Clinical Trial Description

Inhalation anesthesia is still an important source of chemical hazard in the hospital environment due to its widespread use in operating rooms. Factors affecting the presence of anesthetic gases in the environment; device leakage, ventilation, fresh gas flow, and operation of the air cleaning system. Long-term exposure to anesthetic gases is known to adversely affect the health of employees in the operating room. Clara cell plays a reliable role as a large bronchiolar progenitor cell that can contribute to cell regeneration in the bronchial epithelium. Thus, it contributes to the protection of the normal epithelium of the distal conductive airways. Additionally, it has been shown to have immunomodulatory, anti-inflammatory, and antioxidant activity. It is thought that some substances accumulated in the respiratory system participate in the detoxification. Operations of patients undergoing hepatectomy usually take 4-6 hours. Inhalation anesthetics are widely used during this surgery. In this study, we thought to show the effect of long-term inhalation anesthesia exposure by performing this surgery on patients in this group. In this study, we aimed to investigate the effect of sevoflurane and desflurane inhalation anesthetics on clara cell protein in liver transplant donors scheduled for hepatectomy surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04645316
Study type	Interventional
Source	Inonu University
Contact
Status	Completed
Phase	N/A
Start date	November 25, 2020
Completion date	June 20, 2021

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT05054270` - Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Chest Trauma Patients
Not yet recruiting	`NCT04470297` - Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19	Phase 2
Not yet recruiting	`NCT01184313` - Acute Lung Injury After Aortic Valve Surgery	N/A
Not yet recruiting	`NCT06446544` - Functional Residual Capacity and Alveolar Recruitment in Single-lung Ventilation: a Randomized Study	N/A
Not yet recruiting	`NCT06296173` - Open Lung Protective Extubation Following General Anesthesia	N/A
Not yet recruiting	`NCT03661502` - Effect of Variable Volume Ventilation on Lung Compliance	N/A
Recruiting	`NCT04296071` - Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Recruiting	`NCT02299921` - Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
Recruiting	`NCT05559970` - Inhalational Sedation and Mechanical Power	N/A
Completed	`NCT03581006` - Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Trial
Recruiting	`NCT05228717` - Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
Recruiting	`NCT04372953` - Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).	N/A
Not yet recruiting	`NCT05363085` - The Cerebral-Respiratory Interaction in Controlled Mechanically Ventilated Neurosurgical Patients. (The CeRes-CMV Study)
Recruiting	`NCT02444858` - Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury	Phase 1/Phase 2
Completed	`NCT03924206` - Hazardous Surgical Smoke: Risk Assessment and Evaluation of a New Smoke Extractor System in the Surgical Unit
Recruiting	`NCT06416709` - Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases	Phase 1/Phase 2
Withdrawn	`NCT01939067` - Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP	Phase 1
Recruiting	`NCT05401474` - Individualization Flow in Patients Treated With High Flow Nasal Therapy (iFLOW)	N/A
Completed	`NCT03437499` - Adrenomedullin Changes After Sustained Inflation or Positive Pressure Ventilation at Birth	N/A
Not yet recruiting	`NCT05381415` - Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms