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Propylene Glycol/Glycerol Intake and Cardiorespiratory Function — PGGICF  

Lung Injury Clinical Trial

Official title:
Reversibility of Propylene Glycol/Glycerol Intake Effects on Cardiorespiratory Function

Clinical Trial Summary

Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown.

Clinical Trial Description

Background. Propylene glycol/Glycerol intake is increasingly popular. The propylene glycol/glycerol intake effects on cardiorespiratory function are unknown. Weaning of propylene glycol/glycerol could allows a quick clearance of propylene glycol/glycerol from the body, with subsequent recovery of cardiorespiratory function. Specific aim of the research. This research proposal tests the following hypothesis regarding the reversibility of propylene glycol/glycerol and nicotine intake: - Propylene glycol/glycerol cessation restores cardiorespiratory function. - Chronic propylene glycol/glycerol and propylene glycol/glycerol/nicotine intake induces specific serum and urine proteomics profile, which are partially reversed after cessation. - Chronic propylene glycol/glycerol and propylene glycol/glycerol/nicotine intake induces specific serum and urine metabolomics profile, which are partially reversed after cessation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03410511
Study type Interventional
Source Université Libre de Bruxelles
Contact
Status Completed
Phase N/A
Start date January 15, 2018
Completion date June 30, 2020
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