Lung Injury, Acute Clinical Trial
Official title:
Effects of Oxygen on Lung Tissue During Anesthesia
Collect exhaled breath condensates from patients scheduled for a routine surgical procedure
before, during, and after surgery for measurements of IsoFs
Draw blood from patients scheduled for a routine surgical procedure before, during, and
after surgery for measurements of serum thrombomodulin.
High concentrations of oxygen are routinely administered to patients undergoing routine surgical procedures even though it is highly likely, at least in patients with normal lung function, that this is unnecessary and in fact may be doing unnecessary harm. Therefore, we plan to assess whether there is any evidence of lung injury during surgery resulted from administration of high concentrations of oxygen by measuring Isofurans (IsoFs) in exhaled breath condensate. In our studies in mice that were exposed to high concentrations of oxygen we also found that circulating levels of thrombomodulin were increased. Thrombomodulin is present in endothelial cells and upon injury they release thrombomodulin into the circulation. Endothelial cell injury is known to occur in hyperoxic-induced lung injury. Therefore, in addition to measuring IsoFs in exhaled breath condensate we will also measure plasma concentrations of thrombomodulin as an indicator of endothelial injury. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00498251 -
Prevention of Lung Edema After Thoracic Surgery
|
N/A | |
| Completed |
NCT01597635 -
The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury
|
Phase 2 | |
| Completed |
NCT00141726 -
Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant
|
Phase 2 | |
| Completed |
NCT00996840 -
SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS
|
Phase 2 | |
| Completed |
NCT03651817 -
Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg
|
N/A | |
| Recruiting |
NCT05680831 -
Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air
|
Phase 1 | |
| Completed |
NCT03764319 -
Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO
|
N/A | |
| Completed |
NCT01640990 -
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Intravenous Infusion of GW328267X in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT01114009 -
Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients
|
N/A | |
| Recruiting |
NCT03202641 -
Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients
|
N/A | |
| Completed |
NCT03828630 -
Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients
|
||
| Completed |
NCT03905837 -
Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery
|
Phase 4 | |
| Completed |
NCT03023670 -
Lung Protection and Pediatric Cardiac Surgery
|
N/A | |
| Recruiting |
NCT05647967 -
Features of Regional Perfusion of Lung Consolidation
|
||
| Recruiting |
NCT04289324 -
Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants
|
N/A | |
| Completed |
NCT05610475 -
Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass
|
N/A | |
| Completed |
NCT05647382 -
Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass
|
N/A | |
| Recruiting |
NCT04511923 -
Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT03637530 -
a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries
|
N/A | |
| Completed |
NCT04344184 -
SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)
|
Phase 2 |