Clinical Trials Logo
  1. Home
  2. Lung Injury, Acute
  3. NCT05610475

Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass — CPB  

Lung Injury, Acute Clinical Trial

Official title:
Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass(CPB)

Clinical Trial Summary

More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass. However, the incidence of postoperative acute lung injury due to cardiopulmonary bypass is still as high as 20% to 35%. According to clinical experience, the earlier lung damage is detected, the more successful the treatment will be. On the basis of traditional detection, the investigators found a new indicator, serum calpains, which are easy to obtain and have certain specificity. Importantly, they can predict postoperative acute lung injury within 1 hour after cardiac surgery. It is meaningful that this indicator can provide clinicians with early decision-making advice and immediate treatment for patients who may be at risk.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05610475
Study type Interventional
Source Yangzhou University
Contact
Status Completed
Phase N/A
Start date February 1, 2022
Completion date August 1, 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT00498251 - Prevention of Lung Edema After Thoracic Surgery N/A
Completed NCT01597635 - The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury Phase 2
Completed NCT00141726 - Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant Phase 2
Completed NCT00996840 - SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS Phase 2
Completed NCT03651817 - Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg N/A
Recruiting NCT05680831 - Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air Phase 1
Completed NCT03764319 - Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO N/A
Completed NCT01640990 - A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Intravenous Infusion of GW328267X in Healthy Volunteers Phase 1
Completed NCT01114009 - Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients N/A
Terminated NCT00715338 - Effects of Oxygen on Lung Tissue During Anesthesia N/A
Recruiting NCT03202641 - Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients N/A
Completed NCT03828630 - Lung Ultrasound to Detect Pulmonary Complications in Critically Ill Parturients
Completed NCT03905837 - Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery Phase 4
Completed NCT03023670 - Lung Protection and Pediatric Cardiac Surgery N/A
Recruiting NCT05647967 - Features of Regional Perfusion of Lung Consolidation
Recruiting NCT04289324 - Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants N/A
Completed NCT05647382 - Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass N/A
Recruiting NCT04511923 - Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury Phase 1/Phase 2
Active, not recruiting NCT03637530 - a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries N/A
Completed NCT04344184 - SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) Phase 2