Characterization of Anti-HLA Alloimmunization After Pulmonary Valve Homograft Insertion — CAssIOPé  

Lung Graft Dysfunction Clinical Trial

Official title: Characterization of Anti-HLA Alloimmunization After Pulmonary Valve Homograft Insertion (CAssIOPé)

Status Not yet recruiting

Clinical Trial Summary

This is a prospective, monocentric, observational cohort study whose main objective is to describe the number and rate of patients who developed DSAs (Donor Specific Antibody) at 6 months post-surgery with implantation of a cryopreserved lung homograft.

Clinical Trial Description

Lung homograft is used in a large number of complex malformations. It is accepted that homografts may induce immune reactions in the recipient, but no immunological studies have been carried out to characterize the recipient's immune reactions to the homograft and their potential impact on valve function. In this project, the authors propose to study the immunizing character of cryopreserved lung homografts by identifying the appearance of antibodies directed against the HLA, DSA (Donor Specific Antibodies) molecules of the graft (lung homograft) at 1 month and 6 months after its surgical implantation.The primary objective will be analyzed by describing the rate of patients who developed DSA at 6 months post-surgery with implantation of a cryopreserved lung homograft. ;

Related Conditions & MeSH terms

• Lung Graft Dysfunction

• NCT number: NCT06113224
• Study type: Interventional
• Source: Assistance Publique Hopitaux De Marseille
• Contact: Marien Lenois, PhD
• Phone: +33 491386000
• Email: marien.lenoir@ap-hm.fr
• Status: Not yet recruiting
• Phase: N/A
• Start date: December 2023
• Completion date: June 2027