The Application of the New Magnetic Resonance UTE Technique in Thoracic Lesions

Lung Diseases Clinical Trial

Official title:

The Application of the New Magnetic Resonance Technique-UTE in Thoracic Lesions

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05998707
• Other study ID #: ZDWY.FSK.024
• Status: Recruiting
• Start date: July 1, 2023
• Est. completion date: June 13, 2024

Study information

• Verified date: July 2023
• Source: Fifth Affiliated Hospital, Sun Yat-Sen University
• Contact: Xiaojun Chen
• Phone: +8615820587112
• Email: 422175400[@]qq.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Quantitative characteristic values of lung lesions were obtained by UTE technique, so as to make qualitative diagnosis of benign and malignant lesions. And to explore the clinical feasibility of CT-like technology - high resolution ZTE technology in the diagnosis of pulmonary diseases.

Description:

Ultrashort echo time (UTE) sequence can obtain data from T2* for lung imaging before T2* decays in lung parenchyma with extremely short echo time, which makes up for the defect that conventional MRI cannot clearly display short T2 tissue imaging, and can provide more supplementary information for lung CT scan. There has been a lot of research progress in the evaluation of neonatal lung disease, chronic obstructive airway disease and pneumonia. The 3D UTE sequence developed on this basis has made great progress in improving the resolution, signal-to-noise ratio and shortening the scanning time of lung MR Images, and has successfully obtained submillimeter high-resolution images. The purpose of this study was to explore the value of MRI ultra-short echo technology in the qualitative diagnosis of benign and malignant lung lesions, and to explore the clinical application of CT-like technology - high resolution ZTE technology in the lung.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 150
• Est. completion date: June 13, 2024
• Est. primary completion date: June 13, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Age =18 years old;

2. There are lung lesions, and the solid component is =6mm;

3. Chest CT plain scan or /+ enhanced examination within 4 weeks.

Exclusion Criteria:

1. There are metal implants in the corresponding parts of the chest;

2. MRI contrast agent allergy;

3. Claustrophobia;

4. Pregnant women;

5. High fever;

6. Respiratory failure;

7. Lung lesion biopsy within 4 weeks prior to examination.

Related Conditions & MeSH terms

• Lung Diseases

Locations

Country	Name	City	State
China	Radiography department	Zhuhai	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Fifth Affiliated Hospital, Sun Yat-Sen University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	proton density fat fraction (PDFF)	Determination of proton density fat fraction by magnetic resonance imaging	baseline (before surgery)
Primary	T2 relaxation rate	R2*	baseline (before surgery)
Primary	Magnetization Transfer Ratio (MTR)	Magnetization Transfer Ratio	baseline (before surgery)
Secondary	Subjective rating	rating scale	baseline (before surgery)