Lung Diseases Clinical Trial
Official title:
Effects of Adding Intravenous Lidocaine, Alfentanil Before Bronchoscopic Insertion for Preventing Cough During Bronchoscopic Spraying of Local Anesthetics in Non-intubated Bronchoscoopic Interventions
Cough is the most unwanted response during bronchoscopic interventions for hemodynamic instability, hypoxemia, and interruption of interventions. Topical lidocaine is recommended with a grade evidence in British Thoracic Society guideline. However, severe cough often induces during the initial bronchoscopic spraying of local anesthesia, follows with uneven spraying, spasm or arrythmias. In previous reports, there were many drugs and techniques investigated for preventing cough during broncoscopic spraying. As bronchoscopic interventions need more space and stability of airways to precisely operate on, few studies have focused on the effects of different drugs for preventing cough. In this study, Different intravenous drugs (lidocaine, alfentanil, compared to normal saline) is planned to be injected one minutes before bronchoscopic insertion, the responses to bronchoscopicly spraying local anestheticsuch as cough intensity, BIS levels, ANI, Transdermal O2 and CO2, respiration were recorded and analyzed.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | July 30, 2024 |
Est. primary completion date | April 30, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 65 Years |
Eligibility | Inclusion Criteria: - patients planned to receive bronchoscopic interventions for lung tumors with intravenous anesthesia. Exclusion Criteria: - conventional bronchoscopy without interventions such as EBUS, tracheal tumore excision |
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Cancer Center Hospital | Taipei |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | cough score | cough severity x times Cough severity was graded on a 5-point scale: minimal cough, 1 point; moderate cough, 2 points; severe cough, 3 points; bouts of coughing, 4 points; and series of bouts of coughing, 5 points. | from bronchoscopic spray local anesthetics on vocal cords to the end of spraying on bonchial trees | |
Primary | BIS levels from EEG monitor | the changes of BIS levels (0-100) | from 1 minutes before bronchoscopic insertion to 20 minutes after bronchoscopic interventions | |
Primary | ANI scores from analgesia-nociception monitor (0-100) | the changes of ANI scores (0-100) | from 1 minutes before bronchoscopic insertion to 20 minutes after bronchoscopic interventions | |
Secondary | MAP | mean arterial pressure, mmHg | from bronchoscopic insertion to 20 minutes after completion of local anesthetic spraying | |
Secondary | heart rate | heart rate, beats/ minute | from bronchoscopic insertion to 20 minutes after completion of local anesthetic spraying | |
Secondary | SPO2 | SPO2, % | from bronchoscopic insertion to 20 minutes after completion of local anesthetic spraying | |
Secondary | Transdermal CO2 | Transdermal CO2, mmHg | from bronchoscopic insertion to 20 minutes after completion of local anesthetic spraying | |
Secondary | BTransdermal O2 | Transdermal O2, mmHg | from bronchoscopic insertion to 20 minutes after completion of local anesthetic spraying |
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