Lung Diseases Clinical Trial
Official title:
Bronchoalveolar Lavage Liq To Distinguish Benign and Malignant Pulmonary Diseases
Lipid per oxidation final products and free oxygen radicals are thought as initiator role for developing of cancer in the body. Level of paraoxonase in the patients with cancer varies. In this research, the investigators investigated the contribution of level of serum and bronchoalveolar lavage paraoxonase in the differentiation of benign and malignant lung disease patients. This research includes the patients that are diagnosis of lung cancer (research group) and benign pulmonary disease (control group) participated by accepted fiberoptic bronchoscopy (FOB).
Lipid per oxidation final products and free oxygen radicals are thought as initiator role
for developing of cancer in the body. Level of paraoxonase in the patients with cancer
varies. In this research, the investigators investigated the contribution of level of serum
and bronchoalveolar lavage paraoxonase in the differentiation of benign and malignant lung
disease patients. This research includes the patients that are diagnosis of lung cancer
(research group) and benign pulmonary disease (control group) participated by accepted
fiberoptic bronchoscopy (FOB).
Paraoxonase and Cancer Relations Oxidative stress is one of the important etiologic factor
in carcinogenesis. Serum PON1 activity was found to be significantly lower in patients with
lung cancer than healthy people by Elkiran and her friends et al. Also, gastroesophageal
cancer, meningioma, high-grade glioma and ovarian epithelial was found to be significantly
lower in tumour patients according to control groups in plasma. The relationship between
serum PON1 level and the occurrence of cancer is still unknown. PON1 polymorphism has been
reported to be related with an increased risk of occurrence of cancer in relation to
environmental chemicals.
Reactive oxygen radicals can usually lead to tissue damage by attacking all cell components.
Increased free oxygen radicals and oxidative stress which is formed in the body are one of
the important risk factor in increasing various types of cancer. Lipid peroxidation's final
products and scavenger system components are thought to have for a starter role in
oncogenesis. Carcinogenic radicals that are liposoluble are formed as a result of lipid
peroxidation and PON1 binds with radicals that are liposoluble. PON1 are thought to be
capable to metabolize these radicals that are liposoluble. PON1 activity and oxidative
stress has been suggested to be inversely related in serum and macrophages. Loss of
paraoxonase protective effect may play a role in increasing the sensitivity to genomic
damage which inflammatory oxidants and diets carcinogens caused .
Purpose of this research is to compare serum and bronchoalveolar lavage liqs PON contrasts
between patients with lung cancer and the control group and to determine if the enzyme is
lower in plasma and bronchoalveolar lavage liqs in case of malignant.
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Allocation: Non-Randomized, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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