Lung Diseases Clinical Trial
To identify sarcoidosis susceptibility genes and to determine how these genes and environmental risk factors interact to cause sarcoidosis.
BACKGROUND:
Sarcoidosis is a rare systemic granulomatous disease that mainly affects young to middle
aged adults, and more severely affects African Americans than Caucasians. The etiology of
sarcoidosis is not yet known, and epidemiological studies have only identified general risk
factors including age, sex, race, and family history. Sarcoidosis may also be influenced by
environmental factors, although the particular environmental agents have not yet been
clearly defined. While previous studies have provided evidence for familial clustering,
little is known about the genes that influence predisposition to sarcoidosis.
DESIGN NARRATIVE:
This is a multicenter consortium genetic epidemiology study. The investigators will
accomplish their goal by organizing a 10-site multi-center consortium to recruit an adequate
sample of sarcoidosis families for analysis. They plan to use the affected sibling pair
linkage analysis to scan the genome for linked chromosomal regions, transmission
disequilibrium testing to evaluate candidate genes in those regions with evidence for
linkage, and an environmental questionnaire to collect data to test for possible
interactions of susceptibility genes with exogenous risk factors. Genotyping and analysis of
data are scheduled to begin in July, 2001 with completion of all analysis by April, 2004.
The study consists of a Clinical Core, a Data Coordinating Core, and a Genetics Core with a
DNA Processing Center and a Genotyping Center. Eight of the ten clinical centers comprising
the Clinical Core are members of the ACCESS, A Case Control Etiology of Sarcoidosis Study.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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