Lung Diseases Clinical Trial
To establish in children born prematurely a set of links between lung function in late infancy and lung function at school age, between lung function at school age and that in adolescence, and between lung function in adolescence and that in adulthood in order to evaluate pulmonary outcomes of neonatal therapeutic strategies and to relate these strategies to lung health in adult life.
BACKGROUND:
Effective perinatal treatment strategies during the past 20 years have increased the
survival of low birth weight infants. Accompanying this increased survival has been a 4-6
fold increase in the number of children surviving with bronchopulmonary dysplasia, although
the birthweight specific incidence has remained constant or declined. Limited data currently
available indicate that individuals who had BPD as infants have, as childrearing adults,
impaired lung growth as well as both fixed and reversible airways obstruction.
The study was part of an Institute-initiated program on Collaborative Projects in Women's
Health. The concept was developed by the NHLBI staff and given concept clearance at the
February 1992 National Heart, Lung, and Blood Advisory Council. The Request for Applications
was released in April 1992.
DESIGN NARRATIVE:
The study was part of a four-grant collaborative project on women's health. Based on
available data, Dr. Mary Ellen Wohl hypothesized that bronchopulmonary dysplasia (BPD)
morbidity was related to impaired lung growth in the first year of life, did not improve
during adolescence and was accentuated in females because of their intrinsically smaller
lungs. To test this hypothesis, she measured lung size and airway function in teenagers and
young adults, previously studied at school age, who were born, 1) at term, 2) prematurely,
3) developed respiratory distress syndrome of the newborn (RDS) or 4) developed BPD.
Children born from 1987-89 previously studied at 10 months of age by novel lung function
function methods developed in this laboratory were restudied at school age. Techniques of
measuring total respiratory system compliance and resistance and of obtaining forced
expiratory flow at functional residual capacity were applied to cohorts of born premature
infants at 10-18 months of age to assess outcome of current perinatal strategies.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
;
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05563701 -
Evaluation of the LVivo Image Quality Scoring (IQS)
|
||
| Completed |
NCT04908397 -
Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension
|
Phase 1 | |
| Terminated |
NCT03309358 -
A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis
|
Phase 1 | |
| Completed |
NCT03682354 -
ESPB Versus INB With PCIA in Video-assisted Thoracic Surgery
|
N/A | |
| Enrolling by invitation |
NCT03683186 -
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
|
Phase 3 | |
| Completed |
NCT03626519 -
Effects of Menthol on Dyspnoea in COPD Patients
|
N/A | |
| Recruiting |
NCT06004440 -
Real World Registry for Use of the Ion Endoluminal System
|
||
| Completed |
NCT04874948 -
Absorption, Elimination and Safety of 14C-labeled Radioactive BTZ-043, a New Compound in TB Treatment
|
Phase 1 | |
| Completed |
NCT02926768 -
Phase I/II Study of CK-101 in NSCLC Patients and Other Advanced Solid Tumors
|
Phase 1 | |
| Completed |
NCT01443845 -
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
|
Phase 4 | |
| Completed |
NCT00281216 -
Innate and Adaptive Immunity in Individuals Experiencing Chronic Obstructive Pulmonary Disease Exacerbations
|
N/A | |
| Terminated |
NCT00233207 -
IC14 Antibodies to Treat Individuals With Acute Lung Injury
|
Phase 2 | |
| Completed |
NCT00269256 -
Stress, Environment, and Genetics in Urban Children With Asthma
|
N/A | |
| Recruiting |
NCT00129350 -
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation
|
Phase 1 | |
| Active, not recruiting |
NCT00115297 -
Montelukast for Early Life Wheezing
|
Phase 2/Phase 3 | |
| Completed |
NCT00091767 -
Genetic Studies in Difficult to Treat Asthma: TENOR
|
N/A | |
| Completed |
NCT00094276 -
Intervention for Improving Asthma Care for Minority Children in Head Start
|
N/A | |
| Completed |
NCT00089752 -
Continuous Positive Airway Pressure to Improve Milder Obstructive Sleep Apnea
|
N/A | |
| Completed |
NCT00233168 -
Effectiveness of Public Health Model of Latent Tuberculosis Infection Control for High-Risk Adolescents
|
N/A | |
| Completed |
NCT00069823 -
Study of Acid Reflux in Asthma
|
Phase 3 |