Immunological Characterization of Bronchoalveolar Cells in Normals

Status Completed

Clinical Trial Summary

To obtain the monocytes (white blood cells) from normal volunteers for the purpose of studying how proteins, fats, carbohydrates, as well as RNA and DNA for gene expression, relate to immunity. This information will be compared to other studies in patients with lung diseases such as Emphysema, Sarcoidosis, and Interstitial Pulmonary Fibrosis.

Clinical Trial Description

To determine the functional capabilities of cells obtained from bronchoalveolar lavage fluid and peripheral blood monocytes from normal individuals. The ongoing objective varies from investigation to investigation but in general the investigational goals are to better understand the immune function of monocytes purified from normal volunteers. In some instances the emphasis will be upon comparing the specific immune function (e.g. ability to sense endotoxin and release a cytokine) from blood monocytes as compared to human alveolar macrophages. This comparison is not the only goal of the study, however. In many cases the immune function of the monocyte will be sufficient in and of itself as an investigational goal. In other cases the same is true of alveolar macrophage function. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00843414
Study type	Observational
Source	Ohio State University
Contact
Status	Completed
Phase	N/A
Start date	March 1978
Completion date	April 2011

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT02253667` - Palliative Use of High-flow Oxygen Nasal Cannula in End-of-life Lung Disease Patients	N/A
Completed	`NCT02217423` - Abdominal Circumference and Cardiorespiratory Repercussions in Patients Submitted to Physical Therapy	N/A
Completed	`NCT01679301` - Evaluation of Sleep Mode Within the Respironics SimplyGo Portable Oxygen Concentrator	N/A
Completed	`NCT02345135` - Susceptibility to Infections in Ataxia Telangiectasia	N/A
Terminated	`NCT00966823` - Fetal Tracheal Balloon Study in Diaphragmatic Hernia	Phase 2
Completed	`NCT00139152` - Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair	Phase 4
Completed	`NCT00052052` - An Open-Label Study of the Safety and Efficacy of Subcutaneous Recombinant Interferon-Gamma 1b (IFN-Gamma 1b) in Patients With Idiopathic Pulmonary Fibrosis (IPF)	Phase 2
Completed	`NCT00013949` - Cardiovascular Vulnerability to Particulate Exposure	N/A
Recruiting	`NCT02963467` - Effect of Smoking on Ventilation-Perfusion Ratio	N/A
Recruiting	`NCT02965300` - The Value of VOCs Analysis in Exhaled Breath for Pulmonary Benign and Malignant Lesion Diagnosis	N/A
Enrolling by invitation	`NCT02946658` - Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells In Chronic Lung Disorders	Phase 1/Phase 2
Recruiting	`NCT02913365` - Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis	N/A
Completed	`NCT01952002` - Clinical Safety for the Inspiratory Muscle Training	N/A
Completed	`NCT01735526` - Lung Diffusing Capacity for Nitric Oxide and Carbon Monoxide After Hematopoietic Stem-cell Transplantation	N/A
Recruiting	`NCT01450644` - Evaluation of the Hospital2Home Palliative Care Service for Patients With Advanced Progressive Lung Disease	Phase 2
Completed	`NCT01215279` - AZD2423 Safety and Tolerability Study in Patients With Moderate and Severe Chronic Obstructive Pulmonary Disease(COPD)	Phase 2
Completed	`NCT01153321` - Investigation of the Effect of Oral Treatment With 100 mg AZD2423 in Subjects With Mild Chronic Obstructive Pulmonary Disease (COPD)	Phase 2
Completed	`NCT00837681` - Pulmonary Complications of Hematopoietic Stem Cell Transplantation	N/A
Completed	`NCT02055222` - Clinical Outcomes and Molecular Phenotypes in Smokers With Parenchymal Lung Disease
Completed	`NCT01222442` - To Evaluate the Effect of AZD3199 on the Electrical Activity in the Heart	Phase 1