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The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis

Lung Cancer Clinical Trial

Official title:
A Single-center, Prospective, Randomized Controlled Study of the Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis

Clinical Trial Summary

The goal of this single-center prospective randomized controlled trial is to test and compare the safety and effectiveness of autologous blood transfusion in spinal surgery for lung cancer spinal metastases. The main questions it aims to answer are: - Does autologous blood transfusion increase the incidence of new metastases? - Does autologous blood transfusion affect postoperative hemoglobin levels and the number of circulating tumor cells in the blood? - Can autologous blood transfusion reduce the rate of allogeneic transfusion during and after surgery for spinal metastases?

Clinical Trial Description

In this study, participants underwent standard open spinal decompression surgery, and when blood transfusion was needed, autologous blood transfusion or allogeneic blood transfusion was used. Participants will be patients with lung cancer spinal metastases. Investigators will use flow cytometry, immunohistochemistry, and tumor cell culture methods to measure the number of circulating tumor cells in the blood before and after autologous blood transfusion. Investigators will compare participants who receive autologous blood transfusion with those who do not to observe if there are differences in: - The incidence of new metastases - The rate of allogeneic transfusion during and after surgery - Postoperative hemoglobin levels - The number of circulating tumor cells in the blood - The cost associated with transfusion ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06244264
Study type Interventional
Source Guangdong Provincial People's Hospital
Contact Yu Zhang, Ph.D.
Phone 8613602744495
Email luck_2001@126.com
Status Not yet recruiting
Phase N/A
Start date March 15, 2024
Completion date December 31, 2027
View Details
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