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Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors — TIG-006  

Lung Cancer Clinical Trial

Official title:
A Multicenter, Open-Label, Phase I/II Study of EOS884448 (EOS-448) in Combination With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors

Clinical Trial Summary

This is a multicenter, open-label, phase I/II basket study, evaluating the safety, tolerability, RP2D, pharmacokinetics, pharmacodynamics and antitumor activity of EOS-448 (also known as GSK4428859A or belrestotug) combined with standard of care and/or with investigational therapies in participants with advanced solid tumors.

Clinical Trial Description

The combinations evaluated will be: - EOS-448 combined with pembrolizumab, an anti-PD-1 antibody - EOS-448 combined with inupadenant an investigational adenosine A2A receptor antagonist - EOS-448 combined with dostarlimab an anti-PD-1 antibody - inupadenant combined with dostarlimab - EOS-448 combined with inupadenant and dostarlimab - EOS-448 combined with dostarlimab and standard of care chemotherapies in participants with NSCLC ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05060432
Study type Interventional
Source iTeos Therapeutics
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date September 6, 2021
Completion date July 2025
View Details
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