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Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Release for Advanced Solid Tumors

Lung Cancer Clinical Trial

Official title:
Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Released by Interventional Approaches for Advanced Solid Tumors

Clinical Trial Summary

To study the safety and clinical effects of intratumor injecting CpG-ODN and in situ release of tumor antigen by interventional ablation or drug-eluting beads to treat advanced solid tumors.

Clinical Trial Description

1. Percutaneous microwave ablation or intratumor injection of drug-eluting beads to destroy cancer cells to release tumor-specific antigens 2. Intratumor injection of type A/C CpG-ODN with or without infusion of CAR-T cells secreting scFv against OX40 3. Assessing side effects and therapeutic efficacy after the combined treatments ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04952272
Study type Interventional
Source Second Affiliated Hospital of Guangzhou Medical University
Contact Zhenfeng Zhang, MD, PhD
Phone +862039195966
Email zhangzhf@gzhmu.edu.cn
Status Recruiting
Phase Phase 1
Start date March 1, 2021
Completion date June 30, 2036
View Details
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