Serratus Anterior Plane Block Versus Intercostal Nerve Block for Postoperative Analgesia

Lung Cancer Clinical Trial

Official title:

Serratus Anterior Plane Block vs. Intercostal Nerve Block for Postoperative Analgesic Effect After Video-assisted Thoracoscopic Lobectomy: A Randomized Prospective Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04250272
• Other study ID #: 2019-07-008-002
• Status: Recruiting
• Phase: N/A
• Start date: August 16, 2019
• Est. completion date: February 29, 2020

Study information

• Verified date: January 2020
• Source: Kyungpook National University Hospital
• Contact: Jimin Heo
• Phone: +82-53-420-5430
• Email: knuhmrc[@]knu.ac.kr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A prospective randomized controlled study was undertaken to compare the postoperative analgesic effect between ultrasound-guided serratus anterior plane block and intercostal nerve block after video-assisted thoracoscopic lobectomy.

Description:

Post-thoracotomy pain is one of the most notorious postsurgical pains that one can experience. The pain is known to last for an extensive period of time with significantly high intensity.

In field of thoracic surgery, video-assisted thoracoscopic surgery has been played an important role in alleviating the postoperative pain. In field of anesthesiology, various attempts to alleviate post-thoracotomy pain have been tried along advancement of thoracic surgical techniques. It began with postoperative medication of non-steroid anti-inflammatory drugs, opioids and progressed into implementations such as local analgesia, thoracic epidural block, paravertebral block, intercostal nerve block, interpleural block and serratus anterior plane block.

Many analgesic methods have been applied to alleviate postoperative pain in patients who have undergone thoracoscopic surgeries. However, there are no prospective randomized controlled studies between intercostal nerve block and serratus anterior plane block in video-assisted thoracoscopic lobectomy. The main purpose of this study is to compare and analyze the effects between conventional intercostal nerve block and newly introduced serratus anterior plane block in lung cancer patients who have undergone video-assisted thoracoscopic lobectomy.

This prospective study will discover the efficacy and differences between two methods.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: February 29, 2020
• Est. primary completion date: January 31, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• lung cancer

• American Society of Anesthesiologists (ASA) I-III class

• Video-assisted thoracoscopic lobectomy

Exclusion Criteria:

• previous history of allergy to local anesthetics

• psychological disorder

• chronic analgesics or sedatives use

• coagulopathy

• The presence of systemic infection or local infection at injection site

• Pregnancy

Related Conditions & MeSH terms

• Analgesia
• Lung Cancer
• Pain, Postoperative
• Postoperative Pain

Intervention

Procedure:
• Thoracoscopic lobectomy
Thoracoscopic lobectomy was performed for lung cancer

Locations

Country	Name	City	State
Korea, Republic of	Kyungpook national university hospital	Daegu

Sponsors (1)

Lead Sponsor	Collaborator
Kyungpook National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postoperative pain: numeric rating scale	Postoperative pain will be evaluated using a numeric rating scale (0 being no pain, 10 being worst pain imaginable)	at postanesthesia care unit (PACU)
Primary	Postoperative pain: numeric rating scale	Postoperative pain will be evaluated using a numeric rating scale (0 being no pain, 10 being worst pain imaginable)	3 hours later operation
Primary	Postoperative pain: numeric rating scale	Postoperative pain will be evaluated using a numeric rating scale (0 being no pain, 10 being worst pain imaginable)	6 hours later operation
Primary	Postoperative pain: numeric rating scale	Postoperative pain will be evaluated using a numeric rating scale (0 being no pain, 10 being worst pain imaginable)	12 hours later operation
Primary	Postoperative pain: numeric rating scale	Postoperative pain will be evaluated using a numeric rating scale (0 being no pain, 10 being worst pain imaginable)	24 hours later operation
Secondary	Number of analgesics consumption	If the participant has additional analgesic requirement postoperatively, ketorolac 30mg will be injected intravenously when numeric rating scale score is measured as 4-5, and fentanyl 50# is injected when numeric rating scale score is over 6.	through study completion, an average of 1 yea
Secondary	Amount of analgesics consumption	If the participant has additional analgesic requirement postoperatively, ketorolac 30mg will be injected intravenously when numeric rating scale score is measured as 4-5, and fentanyl 50# is injected when numeric rating scale score is over 6.	: through study completion, an average of 1 year