National Register Studies in Thoracic Surgery

Lung Cancer Clinical Trial

Official title:

National Register Studies in Thoracic Surgery

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03567538
• Other study ID #: NatRegThx
• Status: Active, not recruiting
• Start date: January 1, 2018
• Est. completion date: January 2025

Study information

• Verified date: October 2023
• Source: Karolinska University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The overall project aim is to study risk and outcomes following thoracic surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant patient data.

Description:

The purpose of this research project is to study risks and outcomes in patients who underwent thoracic surgery, primarily for lung cancer. We aim to establish a fundament for the conduct of nationwide population-based studies by linking patient-level data from the Swedish quality register for thoracic surgery (ThoR) and other national health-data registers maintained by the government agencies Statistics Sweden and the National Board of Health and Welfare. Cross-linking patient-level data is possible through the Personal Identity Number assigned to every individual who has resided in Sweden on a permanent basis. The Swedish Personal Identity Number is the unique identifier in all national registers.

Specifically, we aim:

1. To analyze the association between socioeconomic factors and prognosis in patients undergoing pulmonary resection for lung cancer.

2. To investigate the implementation of minimally invasive surgery for lung cancer in Sweden.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 20000
• Est. completion date: January 2025
• Est. primary completion date: January 2025
• Gender: All
• Age group: 18 Years to 110 Years

Eligibility

Inclusion Criteria:

All adult patients who underwent thoracic surgery in Sweden during the study period

Exclusion Criteria:

-

Related Conditions & MeSH terms

• Lung Cancer
• Neoplasm Metastasis
• Pulmonary Metastasis
• Surgery

Intervention

Procedure:
• Thoracic surgery
Thoracic surgery, pulmonary resection, minimally invasive thoracic surgery, video assisted thoracic surgery (VATS)

Locations

Country	Name	City	State
Sweden	Karolinska University Hospital	Stockholm

Sponsors (2)

Lead Sponsor	Collaborator
Karolinska University Hospital	Karolinska Institutet

Country where clinical trial is conducted

Sweden, 

References & Publications (5)

Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Video-assisted thoracoscopic versus open thoracotomy lobectomy: a Swedish nationwide cohort study. J Thorac Dis. 2018 Jun;10(6):3499-3506. doi: 10.21037/jtd.2018.05.177. Erratum In: J Thorac Dis. 2020 Apr;12(4):1645. — View Citation

Al-Ameri M, Persson M, Bergman P, Franco-Cereceda A, Sartipy U. Surgery for pulmonary metastases from colorectal cancer: survival and prognostic factors. J Thorac Dis. 2018 Jun;10(6):3372-3380. doi: 10.21037/jtd.2018.05.120. — View Citation

Jackson V, Al-Ameri M, Sartipy U. Weekday and Survival After Pulmonary Resections for Lung Cancer: A Swedish Nationwide Cohort Study. Chest. 2018 May;153(5):1284-1286. doi: 10.1016/j.chest.2018.03.022. No abstract available. — View Citation

Sachs E, Jackson V, Sartipy U. Household disposable income and long-term survival after pulmonary resections for lung cancer. Thorax. 2020 Sep;75(9):764-770. doi: 10.1136/thoraxjnl-2019-214321. Epub 2020 Jun 20. — View Citation

Sachs E, Sartipy U, Jackson V. Sex and Survival After Surgery for Lung Cancer: A Swedish Nationwide Cohort. Chest. 2021 May;159(5):2029-2039. doi: 10.1016/j.chest.2020.11.010. Epub 2020 Nov 17. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	All-cause mortality	Death from any cause	15 years
Secondary	Postoperative complications	Complications related to surgery	30 days