Cancer Development In Organ Transplant Recipients

Lung Cancer Clinical Trial

Official title:

Cancer Development In Organ Transplant Recipients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02333279
• Other study ID #: FUP062
• Secondary ID: snctp000000587
• Status: Completed
• Start date: May 2008
• Est. completion date: July 2019

Study information

• Verified date: July 2019
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis. Secondly the investigators will try to characterize the different cancer types.

Description:

This cohort analyses will focus on incident and recurrent cases of development of non-skin cancer over time. We will consider time to first formation of non-skin solid cancer after solid organ transplantation as well as the cumulative number of non-skin solid cancer formation over time. Both aspects are equally important and will be reflected in the analytic methods of this study. Theses analyses will be restricted to the most prevalent transplantation types of heart, kidney, liver, and lung.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1800
• Est. completion date: July 2019
• Est. primary completion date: May 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

We will select all patients within the STCS based on the date of the first solid organ transplantation. Patients with multiple organ transplantations will be included as well. Patients contribute to the study observation time until death or end of follow-up due to other reasons.

Exclusion Criteria:

We will exclude patients with non-solid organ transplantation (e.g. hematopoietic stem cell transplantation), because the detailing of information in the STCS is insufficient to allow for detailed analysis of cancer development and control of relevant confounders. We will exclude

Related Conditions & MeSH terms

• Carcinoma, Renal Cell
• Heart Cancer
• Kidney Cancer
• Kidney Neoplasms
• Liver Cancer
• Liver Neoplasms
• Lung Cancer
• Pancreas Cancer
• Pancreatic Neoplasms

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich, Division of Dermatology	Zurich

Sponsors (6)

Lead Sponsor	Collaborator
University of Zurich	Cantonal Hospital of St. Gallen, University Hospital Inselspital, Berne, University Hospital, Basel, Switzerland, University Hospital, Geneva, University of Lausanne Hospitals

Country where clinical trial is conducted

Switzerland, 

References & Publications (1)

Lengwiler E, Stampf S, Zippelius A, Salati E, Zaman K, Schäfer N, Schardt J, Siano M, Hofbauer G, The Swiss Transplant Cohort Study. Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study. Swiss Med Wkly. 20 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of solid cancers	Number of solid cancers	Ten Year followup