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Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer

Lung Cancer Clinical Trial

Official title:
Correlation of [D10] Phenanthrene Metabolism With Bronchoepithelial Dysplasia and Metaplasia in Smokers at High Risk for Lung Cancer

Clinical Trial Summary

This clinical trial studies deuterated phenanthrene tetraol in smokers who are at high risk for lung cancer. Studying samples of urine in the laboratory from smokers who are at high risk for lung cancer may help doctors learn more about biomarkers related to cancer.

Clinical Trial Description

PRIMARY OBJECTIVES:

I. To determine the relationship between urinary deuterated ([D10]) phenanthrene tetraol (PheT) level, PheT:phenanthrols (HOPhe) ratio, and the presence of bronchoepithelial metaplasia and/or dysplasia in smokers who have undergone screening bronchoscopy at Roswell Park Cancer Institute (RPCI).

OUTLINE:

Patients receive deuterated phenanthrene tetraol orally (PO). Urine samples are collected for laboratory studies for 6 hours after dosing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01673711
Study type Observational
Source University of Minnesota - Clinical and Translational Science Institute
Contact
Status Completed
Phase
Start date July 2012
Completion date September 30, 2019
View Details
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