Lung Cancer Clinical Trial
Official title:
Early Detection of Lung Cancer - A Pan Canadian Study
RATIONALE: Screening may help doctors find lung cancer sooner, when it may be easier to
treat.
PURPOSE: This clinical trial is studying screening methods to see how well they find lung
cancer early in current or former smokers.
OBJECTIVES:
- To develop a new multi-modal screening strategy and integrated methods to detect lung
cancer early in current and former smokers.
- To evaluate the impact of the screening modalities on the quality of life of these
participants.
- To develop a decision analytic framework for determining the cost and effectiveness of
a novel lung cancer screening strategy in Canada.
OUTLINE: This is a multicenter study.
Participants undergo spirometry at baseline. Participants also undergo spiral CT scan at
baseline and then at 1 and 2 years. Participants with semi-solid or solid nodules of 5-10 mm
or ground glass opacity (GGO) 8-10 mm or those with growth of an existing nodule,
development of a solid component in GGO, or a new nodule undergo an additional CT scan at 3
months. Some participants also undergo autofluorescence and white light bronchoscopy and
bronchial biopsies.
Blood samples are collected at baseline and then annually for 2 years for biomarker studies.
Participants diagnosed with lung cancer undergo additional blood sample collection for
biomarker studies.
Participants complete questionnaires on sociodemographic factors, smoking, occupational
exposure, family history, medical data, quality of life, and anxiety at baseline and then
every 6 months for up to 2 years.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
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