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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT02372032
Other study ID # 2014ZDSYLL134
Secondary ID
Status Active, not recruiting
Phase Phase 3
First received February 6, 2015
Last updated July 12, 2016
Start date February 2015
Est. completion date September 2016

Study information

Verified date July 2016
Source Zhongda Hospital
Contact n/a
Is FDA regulated No
Health authority China: Ministry of Health
Study type Interventional

Clinical Trial Summary

Lumbar disc herniation (LDH) is a common pathological process leading to spinal surgery. Open discectomy used to be a widespread procedure for surgical treatment for symptomatic LDH. Currently, several minimal invasive surgeries have been uesd widely. Percutaneous lumbar discectomy(PLD) and ozone therapy are two widely used minimal invasive treatment, and ozone therapy combined other minimally invasive treatment could improve other minimally invasive treatment's clinical effectiveness. The effectiveness of which has been proved to be comparable to conventional open discectomy.

In this study, a single-blind randomized controlled trial will be performed to evaluate the effectiveness of two minimal invasive discectomy, percutaneous lumbar discectomy combined with ozone and percutaneous lumbar discectomy, for the treatment of symptomatic LDH.

Two groups of patients will be investigated; 1) patients diagnosed with lumbar disc herniation undergoing PLD combined with ozone, and 2) patients diagnosed with lumbar disc herniation undergoing PLD.

The primary endpoints of the study will be changes in in pain and functional status by the Visual Analog Scale (VAS) and functional status as measured by Oswestry Low Back Disability Questionnaire (Oswestry Disability Index,ODI) and Japanese Orthopaedic Association (JOA) as measured at pre- and post-operation, 1 month, 3 months, 6 months. Secondary outcomes include response evaluation by MacNab response evaluation criteria as measured at pre- and post-operation, 1 month, 3 months, 6 months. Treatment effect is defined as the difference in the mean change from baseline between the two groups.

For the first time,the results of this trial will provide scientific evidence as to the relative effectiveness of PLD combined with ozone versus PLD for minimal invasive surgical treatment for symptomatic lumbar disc herniation.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 70
Est. completion date September 2016
Est. primary completion date September 2016
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Age older than 18 years.

- 4 or more weeks low back pain and/or lower-limb radiation pain.

- MRI and/or CT test confirm diagnosis lumbar disc herniation and level(s).

- Invalid after Non-steroidal anti-inflammatory medical therapy and physical therapy.

- Pain level(Visual Analog Scale)=5.

Exclusion Criteria:

- Spinal tumors.

- Spine infections, fractures, slippage(more than I °) and other deformities.

- Combining with spinal stenosis, lateral recess stenosis, yellow ligament hypertrophy.

- Nucleus pulposus herniated too much, dural sac compressed more than 50%;

- Psychological, cognitive disorders which may affect the reliability of the outcome;

- Previous lumbar disc surgery;

- Bleeding tendency or severe cardiovascular disease can not tolerate surgery;

- Don't accept the trial's informed consent;

- Possible pregnancy.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Treatment


Intervention

Procedure:
percutaneous lumbar discectomy
process percutaneous lumbar discectomy
ozone therapy
percutaneous intradiscal ozone injection

Locations

Country Name City State
China Zhongda Hospital,Southeast University Nanjing Jiangsu

Sponsors (1)

Lead Sponsor Collaborator
Zhongda Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Changes from baseline in Visual Analog Scale(VAS) Baseline, post-op 1 month, 3 months, 6 months No
Primary Changes from baseline in Oswestry Low Back Disability Questionnaire(ODI) Baseline, post-op 1 month, 3 months, 6 months No
Primary Changes from baseline in Japanese Orthopaedic Association Scores(JOA) Baseline, post-op 1 month, 3 months, 6 months No
Secondary Response evaluation measured by MacNab criteria Response evaluation as measured by MacNab criteria post-op 1 month, 3 months, 6 months No
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