Low Back Pain Clinical Trial
Official title:
Cayenne Pepper Cataplasm Application and Potential Side Effects
The beneficial analgesic effects of Rubefacenciae (redden skin substances), is known since
1830 as a treatment for pain, cramps, and disorders of the musculoskeletal system. Herbal
cataplasms containing rubefacient substances, such as Cayenne pepper, are commonly used as
natural medications to treat painful or aching areas in the case of acute or chronic back
pain, and rheumatisms. In Vienna and lower Austria, a Cayenne Pepper Cataplasm (CPC)
application containing Cayenne pepper and Kaolin powder in mixed proportion, is commonly used
to treat musculoskeletal conditions of pain especially of the low back. However, a concern
about the safety of such applications was recently raised.
Therefore, the aims of the present study are to evaluate the effects of 10x 20min CP
cataplasm application as a single treatment or in combination with electrical stimulation and
massage on selected functional and molecular parameters on i) healthy subjects and ii)
subjects suffering from low back pain.
Musculoskeletal diseases, such as neck and low back pain, are widespread disorders in many
developed countries. Their management is challenging, and it may have mounting socioeconomic
burden. Several evidences in the literature demonstrate the efficacy of many therapeutic
strategies in the treatment of these conditions, based on pharmacological or surgical
interventions. Physical medicine therapies are good alternatives that may have beneficial
effects, especially when used as first line of intervention before approaching more expensive
pharmacological or invasive medications. The beneficial analgesic effects of Applicatio
Epispasticorum of Rubefacenciae (redden skin substances), is known since 1830 as a treatment
for pain, cramps, and disorders of the musculoskeletal system. Herbal cataplasms containing
rubefacient substances, such as Cayenne pepper (CP), are commonly used as natural medications
to treat painful or aching areas in the case of acute or chronic back pain, and rheumatisms.
They are also used in pain involving joints caused by osteoarthritis. A galenic preparation
composed of rubefacient substances of vegetable origin, which generated vasodilation and
increase in blood circulation on the treated areas, was first prescribed in 1909 by Dr.
Giuseppe Munari to treat pain of various areas of the locomotive system. He proposed a method
based on applications prepared according to his own galenic formula that have become famous
all over Italy and Europe. In Vienna and lower Austria, a Munari-like application containing
CP and Kaolin powder in mixed proportion, is commonly used to treat musculoskeletal
conditions of pain especially of the low back. The research on responses to CPC applications,
particularly in combination with other modalities is scarce.
Therefore, the aims of the present study are firstly to evaluate the effects of 10x 20min CP
cataplasm application on selected functional and molecular parameters on healthy subjects.
Then, the same applications will be used on subjects suffering from low back pain (LBP) -
both as a single treatment and in combination with electrical stimulation and massage.
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