Localized Gingival Recession Clinical Trial
Official title:
PriMatrix Utilization to Achieve Dental Root Coverage
Can a fetal bovine derived membrane serve as an alternative to autogenous tissue for dental root coverage procedures.
PriMatrix (TEI Medical Inc) is a promising collagen membrane derived from fetal bovine
dermis. The acellular porous structure of the membrane permits rapid re-vascularization and
cellular re-population. The membrane contains a high proportion of type III collagen. Type
III collagen helps regulate tissue healing by promoting neoepithelialization and
angiogenesis. Wounds grafted with PriMatrix exhibited significantly faster healing rates
compared to control wounds while having a minimal foreign body response and early
repopulation by progenitor cells.
The ability of PriMatrix to permit neovascularization, reepithelialization, minimal immune
response, and population by progenitor cells suggests that it may serve as an ideal
alternative to CTG under CPF for root coverage. In this regard, the current study aims to
serve as a pilot to test the feasibility of the use of PriMatrix as a graft material under a
CPF to attain root coverage of Miller Class I & II defects.
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