Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

Liver Transplantation Clinical Trial

Official title:

Effect of Transfusion of Plasma During Orthotopic Liver Transplantation on Endothelial Glycocalyx Layer and Short-term Outcome in Patients With End-Stage Liver Disease

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04107883
• Other study ID #: LX-2019-LT-1
• Status: Recruiting
• Phase: N/A
• Start date: October 1, 2023
• Est. completion date: December 31, 2024

Study information

• Verified date: November 2023
• Source: Beijing Chao Yang Hospital
• Contact: Xun Liu
• Phone: +86 13466505725
• Email: 13466505725[@]163.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: December 31, 2024
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Child A/B cirrhosis

• patients who undergo the first OLT

• Informed and consented

• complete follow-up

• cooperate with treatment

Exclusion Criteria:

• re-transplant

• combined liver and other organ transplantation

• BMI=30Kg/m2

• patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion

• acute liver failure

Related Conditions & MeSH terms

• End Stage Liver DIsease
• Liver Diseases
• Liver Transplantation

Intervention

Biological:
• fresh frozen plasma
perform plasma transfusion in different phases during perioperation

Diagnostic Test:
• blood sample
get blood samples at several specific points in time during perioperation

Locations

Country	Name	City	State
China	Capital Medical University Affiliated Beijing Chaoyang Hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Chao Yang Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	endothelial glycocalyx layer shedding markers	plasma concentration of endothelial glycocalyx layer shedding markers	24 hours
Secondary	inflammatory cytokines	levels of inflammatory cytokines	24 hours