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NCT04107883 Clinical Trial

Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

Liver Transplantation Clinical Trial

Official title:
Effect of Transfusion of Plasma During Orthotopic Liver Transplantation on Endothelial Glycocalyx Layer and Short-term Outcome in Patients With End-Stage Liver Disease

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04107883
Other study ID # LX-2019-LT-1
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date October 1, 2023
Est. completion date December 31, 2024

Study information
Verified date November 2023
Source Beijing Chao Yang Hospital
Contact Xun Liu
Phone +86 13466505725
Email 13466505725@163.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.

Recruitment information / eligibility
Status Recruiting
Enrollment 30
Est. completion date December 31, 2024
Est. primary completion date December 31, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - Child A/B cirrhosis - patients who undergo the first OLT - Informed and consented - complete follow-up - cooperate with treatment Exclusion Criteria: - re-transplant - combined liver and other organ transplantation - BMI=30Kg/m2 - patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion - acute liver failure

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• fresh frozen plasma
perform plasma transfusion in different phases during perioperation
Diagnostic Test:
• blood sample
get blood samples at several specific points in time during perioperation

Locations
Country Name City State
China Capital Medical University Affiliated Beijing Chaoyang Hospital Beijing Beijing

Sponsors (1)
Lead Sponsor Collaborator
Beijing Chao Yang Hospital

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary endothelial glycocalyx layer shedding markers plasma concentration of endothelial glycocalyx layer shedding markers 24 hours
Secondary inflammatory cytokines levels of inflammatory cytokines 24 hours
See also
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