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Anaesthetic and Pediatric Living Related Liver Transplantation

Liver Transplantation Clinical Trial

Official title:
The Effect of Sevoflurane or Propofol on Brain Injury and Neurocognitive in Pediatric Living Related Liver Transplantation

Clinical Trial Summary

To study the effect of different anaesthetic methods on pediatric neurocognitive development and cerebral injury during pediatric living related liver transplantation .

Clinical Trial Description

Since the 1960 s, with the successful development of liver transplantation, it has become an important method for the treatment of patients with end-stage liver disease.Biliary atresia1 is the most frequent causes of pediatric end-stage liver disease,.The morbidity of congenital biliary atresia is 1/8000-18, 0002 ,which influence the patients' overall growth and development situation. The rising of living donor liver transplantation has provide children with the chance of a timely treatment since the 1980 s, It is no doubt that pediatric liver transplantation is facing with many complications, including the most importance of neurocognitive development .Now the researches of neurological complications is less .According to statistics, the incidence of neurological complications after pediatric liver transplantation was 8% - 46% . So it is necessary to research the neurological complications and brain protection strategy .Previous studies have studied that some anaesthetic have uncertain affect on the development of children. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03024840
Study type Interventional
Source Tianjin First Central Hospital
Contact
Status Enrolling by invitation
Phase N/A
Start date December 2016
Completion date December 2017
View Details
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