Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients

Status Completed

Clinical Trial Summary

This is an observational study examining serum markers in patients who are undergoing either a cadaveric liver transplant or a living related liver transplant.

Clinical Trial Description

The Departments of Anesthesiology are conducting an observational trial of markers in the serum of patients who are undergoing liver transplantation surgery. This study will utilize the biological markers, trimethylamine-N-oxide (TMAO), NGAL, and cystatin-C, sensitive markers of renal medullary injury in the blood and allantoin, a marker of oxidative stress as indicators of renal injury in a kidney during liver transplants. It is hypothesized that: (1) these markers are less pronounced in living donor liver transplant recipient patients than in cadaveric liver transplant recipients, and (2) these markers are less pronounced in cadaveric liver transplant recipients in which a "piggy-back" technique was used versus recipients in which a total venous occlusion technique was used. This study will be done in a multi-center format, along with researchers at UCSF ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00698399
Study type	Observational
Source	Vanderbilt University Medical Center
Contact
Status	Completed
Phase	N/A
Start date	March 2008
Completion date	February 2, 2010

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