PET-MRI After Radiofrequency Ablation (RFA) or Microwave Ablation (MWA)

Liver Neoplasms Clinical Trial

Official title: The Use of PET-MRI in the Follow-up of RFA and MWA Treated Colorectal Liver Metastases

Status Completed

Clinical Trial Summary

The primary objective of this study is to evaluate the ability of PET-MRI and to detect a local site recurrence during the first year of follow-up after RFA or MWA of colorectal liver metastases (CRLM) as compared with contrast enhanced (ce) CT and PET-CT. Standard reference will be clear focal uptake in the rim of the lesion on PET-CT, possibly in combination with histology (when available) or clinical follow-up.

Secondary outcomes are the inter-observer variability, the ability to diagnose new intrahepatic lesions and in what way PET-MRI is able to influence future treatment compared to PET-CT and ceCT. The patients satisfaction concerning the PET-MRI will be examined with a questionnaire.

Clinical Trial Description

All included patients will routinely undergo follow-up with 3 monthly ceCT of the liver and PET-CT in the first year after RFA/MWA of CRLM according to standard of care in our hospital. Patients are asked to undergo an additional PET-MRI of the liver on the same day in the first year (in total 4 scans). The PET-MRI is obtained before the PET-CT. The 18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose (FDG) used for PET-CT and PET-MRI are alike and one injection is sufficient. The PET-CT has to be made within 150 minutes after FDG injection. Anonymous PET-MRI results are independently reviewed by 2 experienced radiologists and 2 nuclear medicine physicians twice, with a time-interval of at least two weeks between the first and second review. Based on these results, treatment decisions will be compared for any change in decision making.

The evaluate inter-observer variability we will ask the two nuclear medicine physicians and two radiologist to assess all results and score local and intrahepatic tumor progression. Results of the first and second evaluation will be compared to determine inter observer agreement using Cohen's Kappa. Local recurrence and new lesions will be scored on a separate form with standard criteria.

The reports on LSR will be scored as follows:

• Normal: when the reviewer is sure that no tumor recurrence is present in the ablation zone.

• Probably benign: FDG is enhanced, but compatible with post-ablation inflammation or rim-like characteristics on MRI images (not focal!)

• Equivocal: there is doubt whether the enhanced FDG, CT- or MRI features are due to tumor recurrence or inflammation

• Probably malign: when the reviewer is sure about local recurrence in the ablation zone. Size and location will also be reported.

The reports on new intrahepatic lesions will be scored as follows:

• Normal: no new intrahepatic disease outside 1cm of the ablation zone

• Equivocal: doubt about the malignant origin of a lesion

• Probably malign: new intrahepatic tumor not within 1cm of the ablation zone, including size and location.

The results of all scans by the reviewers, in the way as described above, will be compared to each other to determine the inter-observer variability using Cohen's Kappa.

A questionnaire with 7 questions is completed at the end of one year follow-up to determine patients experience with PET-MRI and PET-CT.

The questions will be in Dutch, but are translated below for this purpose. Patients can answer on a scale 1-5 and n/a.

• The PET-MRI was less burdensome than PET-CT

• The PET-MRI was more bothersome than I expected

• PET-MRI is more comfortable than PET-CT

• If I could choose, I would rather undergo PET-MRI than PET-CT

• The noise of the PET-MRI was annoying

• The fact that PET-MRI takes longer than PET-CT isn't an issue for me

• I would rather undergo a PET-MRI than a PET-CT if results are proven to be equal ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Liver Neoplasms
• Local Neoplasm Recurrence
• Neoplasm Recurrence, Local
• Neoplasms
• Recurrence

• NCT number: NCT01895673
• Study type: Observational
• Source: VU University Medical Center
• Status: Completed
• Phase: N/A
• Start date: June 2013
• Completion date: June 2016