Liver Metastasis Colon Cancer Clinical Trial
Official title:
Immune Response to Irreversible Electroporation (NanoKnife ®) and a Checkpoint Inhibitor With or Without CpG Oligodeoxynucleotides for the Treatment of Stage IV Colorectal Cancer
The goal of this pilot clinical trial is to learn about the combination of immune boosting drugs and irreversible electroporation (IRE) in patients with colon cancer that has spread to the liver (metastasis). The main questions it aims to answer are: 1. to document the rate of complications associated with combining IRE with immune boosting drugs. 2. After one liver metastasis is treated with IRE and immune boosting drugs, what is the change in the size of the non-IRE-treated liver metastases? 3. What is the immune response (measured in a blood sample) when IRE is combined with one or two types of immune boosting drugs?
Single-centre pilot study of the use of IRE for the treatment of 12 patients with unresectable colorectal liver metastases to assess feasibility and gain preliminary data to inform the design of a larger study. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05775146 -
SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases
|
Phase 2 | |
| Suspended |
NCT04108481 -
Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer
|
Phase 1/Phase 2 | |
| Recruiting |
NCT03562234 -
The CLiFF Study: Change in Liver Function and Fat in Pre-operative Chemotherapy for Colorectal Liver Metastases
|
||
| Recruiting |
NCT03732235 -
TACE Associated to Systemic Bevacizumab for the Treatment of Refractory Liver Metastases From Colorectal Cancer
|
||
| Recruiting |
NCT06126419 -
Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
|
N/A | |
| Active, not recruiting |
NCT05616039 -
I-FIGS Feasibility Study
|
N/A | |
| Withdrawn |
NCT05175092 -
Living Donor Liver Transplantation for CRC Liver Metastases
|
N/A | |
| Recruiting |
NCT04798898 -
Improving Survival of COlorectal LIver Metastases by RFA-mediated Immunostimulation
|
N/A | |
| Not yet recruiting |
NCT06071052 -
TACE Plus HAIC Combined With Regorafenib for Liver Metastasis of Colorectal Cancer Refractory to Standard Treatment Regimens
|
N/A | |
| Not yet recruiting |
NCT06053996 -
Hepatopulmonary Radio-sterilization With Immunotherapy
|
N/A | |
| Recruiting |
NCT04491929 -
Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases
|
||
| Not yet recruiting |
NCT06050200 -
TANGO-LIVER Three Arm Nuclear Growth Observation in Liver Surgery
|
N/A | |
| Enrolling by invitation |
NCT03444194 -
Treatment Response Evaluation in Patients With Non-resectable Colorectal Liver Metastases A Feasibility Study
|
N/A | |
| Not yet recruiting |
NCT05884723 -
Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis
|
N/A | |
| Not yet recruiting |
NCT06185556 -
COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05755672 -
On-treatment Biomarkers in Metastatic Colorectal Cancer for Life
|
||
| Recruiting |
NCT04595266 -
Chemoembolization (Lifepearls-Irinotecan) in Patients With Colorectal Cancer and Metastatic Disease
|
Phase 2 | |
| Recruiting |
NCT04701281 -
Study of Intra-Arterial Oxaliplatin Plus Capecitabine to Treat Liver Metastases From Colorectal Cancer
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06200831 -
Simultaneous vs. Staged Resection of Colorectal Cancer With Synchronous Liver Metastases
|
N/A | |
| Active, not recruiting |
NCT04046445 -
Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Stage IV Colorectal Cancer
|
Phase 1 |