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Safety and Efficacy of hiHep Bioartificial Liver Support System to Treat Acute Liver Failure

Liver Failure, Acute Clinical Trial

Official title:
Safety and Efficacy of hiHep Bioartificial Liver Support System to Treat Acute Liver Failure

Clinical Trial Summary

This study tend to evaluate safety and efficacy of hiHep bioartificial liver support system in treating acute liver failure.

Clinical Trial Description

Liver damage remains a life-threatening syndrome. With the increasing number of patients awaiting transplantation, efforts have been made to develop extracorporeal methods to support or replace the function of the failing organ. A bioartificial liver support system has to provide the main functions of the liver: detoxification, synthesis, and regulation. It may prolonger the expected survival time of acute liver failure patients. Direct reprogramming of fibroblasts to hepatic lineages could offer a new type of solution to bioartificial liver support system. The investigators have already generated human induced hepatocytes (hiHeps) from fibroblasts by lentiviral expression of FOXA3, HNF1A, and HNF4A. hiHeps express hepatic gene programs, can be expanded in vitro, and display functions characteristic of mature hepatocytes, including cytochrome P450 enzyme activity and biliary drug clearance. hiHeps can restore the liver function and prolong survival. This study tends to evaluate safety and efficacy of hiHep bioartificial liver support system in treating acute liver failure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03084198
Study type Interventional
Source Shanghai East Hospital
Contact Shaolin Ma, MD.
Phone +8613310167499
Email m_slin@sina.com
Status Not yet recruiting
Phase N/A
Start date June 2017
Completion date June 2020
View Details
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