Liver Cirrhosis Clinical Trial
Official title:
Comparison of Efficacy and Safety of Gastric Variceal Ligation Versus Gastric Variceal Obturation for Secondary Prophylaxis of Gastric Varices
The investigators establish a randomized controlled clinical trial, comparing the efficacy
and prognosis of GVL and GVO in secondary prevention of GVs, especially in patients with
portosystemic shunting, and exploring the endoscopic treatment selection of different types
of GVs.
Outcome expectations: Compared with glue injection, endoscopic ligation for secondary
prevention of gastric varices is safe and effective, especially in patients with
portosystemic shunting.
Gastric varices (GVs) is a common complication of portal hypertension, with an incidence of
20%. Though the bleeding rate of GVs (25%) is lower than that of Esophageal varices (EVs),
the mortality rate is higher due to greater GVs rupture and less space for endoscopic
intervention. In addition, in 30% of patients with GVs, the possibility of treatment failure
exists.
Guidelines differ on endoscopic treatment for secondary prevention of GVs.Current studies
suggest that EVL, due to its low incidence of complications, is suitable for GOV1, while it
is still controversial for the treatment of gastric varices. Compared with glue, the
advantage of ligation is that it can avoid serious complications caused by glue injection,
such as ectopic embolization, large ulcer and sepsis. As there are few studies comparing GVL
and GVO in secondary prevention of gastric varices, the treatment methods are different, and
the treatment effect is controversial. In addition, the choice of treatment for different
types of GVs needs further study.
The investigators establish a randomized controlled clinical trial, comparing the efficacy
and prognosis of GVL and GVO in secondary prevention of GVs, especially in patients with
portosystemic shunting, and exploring the endoscopic treatment selection of different types
of GVs.
Outcome expectations: Compared with glue injection, endoscopic ligation for secondary
prevention of gastric varices is safe and effective, especially in patients with
portosystemic shunting.
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