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Gadolinium Contrast-enhanced Abbreviated MRI (AMRI) vs. Standard Ultrasound for Hepatocellular Carcinoma (HCC) Surveillance in Patients With Cirrhosis

Liver Cancer Clinical Trial

Official title:
Abbreviated MRI (AMRI) vs. Ultrasound for HCC Surveillance in Cirrhosis

Clinical Trial Summary

This study compares gadolinium contrast-enhanced Abbreviated MRI (AMRI) to standard ultrasound for Hepatocellular Carcinoma (HCC) screening and surveillance in subjects with liver cirrhosis.

Clinical Trial Description

Ultrasound (US) is currently used for HCC surveillance. However, US has certain limitations, so physicians use contrast CT or MRI. However, these are expensive and time-consuming procedures. We introduced an abbreviated MRI (AMRI) exam, which works well in cirrhotic and obese patients (unlike US), involves no ionizing radiation (unlike CT), and is rapid (unlike multi-phasic MRI) with total scanner times of less than ten minutes, and can be performed at about the same cost as US. This study in adult patients with cirrhosis will compare the performance of AMRI vs. US for detection of early-stage disease, and will help to define and validate a novel, rapid, accurate, and potentially cost-effective imaging protocol for HCC screening in high-risk individuals. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04288323
Study type Interventional
Source University of California, San Diego
Contact Alexandra Schlein
Phone (858) 246- 2199
Email a1schlein@health.ucsd.edu
Status Recruiting
Phase Phase 4
Start date April 27, 2018
Completion date December 31, 2023
View Details
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