Correlation of Genetic Polymorphism and Livedo Vasculitis

Livedoid Vasculitis Clinical Trial

Official title:

Correlation of Genetic Polymorphism and Livedo Vasculitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00975871
• Other study ID #: 0961172000
• Status: Completed
• Phase: N/A
• First received: September 11, 2009
• Last updated: October 21, 2009
• Start date: October 2007
• Est. completion date: April 2009

Study information

• Verified date: October 2009
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars. The actual mechanism of its pathophysiology is not yet clear. It has been reported to be associated with some gene mutations, for example, factor V Leiden gene. This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.

Description:

Livedo vasculitis is a chronic, recurrent painful ulcerations on the ankles and feet. This chronic disease is characterized by healed white, atrophic scars named atrophie blanche. The histopathological exam on the lesion site reveals fibrin deposition within the vessel walls. It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. This study is trying to find the correlation between Taiwanese patients and these four genes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: April 2009
• Est. primary completion date: April 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Clinical diagnosis of livedo vasculitis

Exclusion Criteria:

• No special exclusion criteria

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Genetic Pleomorphism
• Leiden Mutation
• Livedo Vasculitis
• Livedoid Vasculitis
• Livedoid Vasculopathy
• Vascular Diseases
• Vasculitis

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan,