Live Birth Clinical Trial
Official title:
A Single Centre Randomised Controlled Study Into the Segmentation of Preimplantation Genetic Diagnosis (PGD) Treatment by Comparing Cumulative Pregnancy Rates Following Cryopreservation of All Genetically Transferable Embryos After PGD, Compared to Fresh Embryo Transfer Cumulative With Frozen Embryo Transfer of Genetically Transferable Embryos.
A single centre observational study into the segmentation of preimplantation genetic
diagnosis (PGD) treatment by comparing cumulative pregnancy rates following cryopreservation
of all genetically transferable embryos after PGD, compared to fresh embryo transfer
cumulative with frozen embryo transfer of genetically transferable embryos.The primary aim
of the study is to assess the feasibility and effectiveness of segmentation in terms of
pregnancy rates. The secondary aim is to assess the logistic advantage of segmentation in
PGD cycles.
Experimental questions
1. Is the cumulative live birth rate rate of a single PGD treatment when all genetically
transferable embryos are cryopreserved by vitrification prior to consecutive in utero
transfer in unstimulated cycles, superior to PGD treatment with fresh embryo transfer
cumulative with transfer of supernumerary cryopreserved embryos?
2. Does the technique of segmentation allow better planning of DNA amplification and
genetic analysis?
Design The proposed design is a pragmatic, prospective randomised controlled trial
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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