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Comparison of Laser Treatment With Clobetasol Therapy in Patients With Lichen Sclerosus

Lichen Sclerosus Clinical Trial

Official title:
Monocentric, Prospective, Randomised, Single Blinded, Active-controlled Trial to Prove That the Treatment With Monalisa Glide is Equal to Topic Clobetasol Propionate Maintenance Therapy in Vulvar Lichen Sclerosus

Clinical Trial Summary

With this trial the investigators look for the effect of Laser maintenance therapy in patients with vulvar lichen sclerosus compared to the maintenance standard treatment clobetasol propionate.

Clinical Trial Description

Vulvar Lichen sclerosus (VLS) is a chronic inflammatory cutaneous disorder, which can lead to scarring, impaired sexual function and malignancy. Gold standard treatment is topical corticosteroids (TCS) initially daily for 12 weeks. To avoid new flourishing of the disease a life-long maintenance treatment 2x/week is later recommended. Fractional CO2-Laser has shown a positive effect on vulvovaginal skin quality with improvement of urogenital atrophy and also lichen sclerosus. This randomised trial compares efficacy of laser treatment to TCS maintenance as well as the duration of the laser effect. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06135402
Study type Interventional
Source Kantonsspital Winterthur KSW
Contact Rebecca R Zachariah, MD
Phone +41522663173
Email rebecca.zachariah@ksw.ch
Status Recruiting
Phase N/A
Start date November 10, 2023
Completion date November 1, 2026
View Details
See also
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Completed NCT05396261 - a Flexible Wound Dressing for the Management of Genital Skin Conditions N/A
Active, not recruiting NCT03525522 - Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus N/A
Recruiting NCT05671263 - Genital Lichen Sclerosus - Epidemiology, Comorbidities and the Role of Vulvar and Penile Microbiome
Completed NCT02732145 - Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis N/A
Completed NCT03665584 - MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus N/A
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