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Lichen Sclerosus Et Atrophicus clinical trials

View clinical trials related to Lichen Sclerosus Et Atrophicus.

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NCT ID: NCT06389071 Recruiting - Clinical trials for Lichen Sclerosus Lesion

Laser Treatment for Lichen Sclerosus

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

Fractional ablative laser treatment for Lichen Sclerosus lesion

NCT ID: NCT06360705 Recruiting - Clinical trials for Vulvar Lichen Sclerosus

StrataMGT for the Treatment of Vulvar Lichen Sclerosus

Start date: April 2024
Phase: N/A
Study type: Interventional

This study is designed to evaluate the efficacy and safety of StrataMGT for the treatment of vulvar lichen sclerosus.

NCT ID: NCT06135402 Recruiting - Lichen Sclerosus Clinical Trials

Comparison of Laser Treatment With Clobetasol Therapy in Patients With Lichen Sclerosus

Start date: November 10, 2023
Phase: N/A
Study type: Interventional

With this trial the investigators look for the effect of Laser maintenance therapy in patients with vulvar lichen sclerosus compared to the maintenance standard treatment clobetasol propionate.

NCT ID: NCT06132919 Recruiting - Clinical trials for Vulvar Lichen Sclerosus

Efficacy and Safety of MC2-25 Cream & Vehicle in Women With Vulvar Lichen Sclerosus (VLS)

Orchid 1
Start date: October 11, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to explore the efficacy and safety of MC2-25 cream and MC2-25 vehicle in women with vulvar lichen schelosus (VLS).

NCT ID: NCT06079645 Recruiting - Clinical trials for Lichen Sclerosus of External Female Genital Organs

Lichen Sclerosus - Treatment With Triamcinolone Acetonide: Injections (Syringe and Needle) x Micro Injections (MMP Technique)

Start date: October 20, 2023
Phase: Phase 4
Study type: Interventional

This research is about a genital disease known as Lichem Sclerosus and Atrophic. It mainly affects women over 18 years of age. The treatment will involve injections of a medicine that contains cortisone, using two different methods: with a syringe and a needle or with a tattoo machine. Before and after treatment, they will see if women feel pain, itching, burning, scratching or difficulty having sexual intercourse.

NCT ID: NCT05953090 Recruiting - Vaginal Atrophy Clinical Trials

VALOR: Vaginal Atrophy & Long-term Observation of Recovery

VALOR
Start date: October 30, 2023
Phase: N/A
Study type: Interventional

Vulvovaginal skin conditions, namely vaginal atrophy, lichen sclerosus, lichen simplex chronicus and lichen planus affecting the female adult population will be treated with a novel gel dressing to test the short- and long-term safety and efficacy of the device.

NCT ID: NCT05671263 Recruiting - Lichen Sclerosus Clinical Trials

Genital Lichen Sclerosus - Epidemiology, Comorbidities and the Role of Vulvar and Penile Microbiome

Start date: January 14, 2022
Phase:
Study type: Observational

In genital LSc, three pathological processes are implicated in disease development: inflammation, sclerosis/fibrosis and neoplasia. The role of genital microbiome is still to be investigated and explained. Genital LSc microbiome studies are missing. The ecological community of microorganisms that are present on our body and of the body itself defines the human skin microbiome. Revealing the genital microbiome may potentially lead to new therapies of genital LSc. The primary aim is to analyze genital microbiome before and after the treatment (topical corticosteroids or topical calcineurin inhibitors or circumcision) in both male and female patients diagnosed with genital LSc as well as to analyze genital microbiome in healthy (non-genital LSc) controls. 2) The secondary aim is to determine incidence and prevalence of male and female genital LSc in Sweden and its association with other diseases. The Study will be divided in two parts 1. PART A: Prospective case control study on the effect of treatment on the genital skin microbiome of patients with genital LSc and on the role of genital microbiome in treatment resistance of genital LSc 2. PART B: Swedish nationwide register-based cohort study to analyse incidence, prevalence and comorbidities of genital LSc

NCT ID: NCT05593445 Completed - Lichen Sclerosus Clinical Trials

A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Lichen Sclerosus

Start date: November 18, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of Ruxolitinib cream in participants With Lichen Sclerosus. This is randomized, double-blind, vehicle-controlled (DBVC) study with a DBVC period of 12 weeks followed by an open label period (OLE) period of 12 weeks.

NCT ID: NCT05464290 Recruiting - Urethral Stricture Clinical Trials

The Nanofat Regenerative Surgery for Management of Genital Lichen Sclerosus in Male and Female Patients

LSNanofat
Start date: July 25, 2022
Phase: N/A
Study type: Interventional

Regenerative surgery is an emerging multidisciplinary field actually based on derived adipose tissue. Autologous fat grafting was first described by Neuber in 1893 and since then it has developed over the next century. The initial goal of fat grafting was to treat volume losses created by disease or trauma. Further studies done by Zuk et al. in 2001 showed that lipoaspirate contains multipotent adipose stem cells (ADSCs) like in the bone marrow, thereby expanding opportunities in multiple fields. ADSCs have emerged as a key element of regenerative medicine surgery due to their ability to differentiate into a variety of different cell lineages. Moreover, their capacity of paracrine secretion of a broad selection of cytokines, chemokines, and growth factors make them highly clinically attractive. More specific, of particular interest are the anti-apoptotic, anti-inflammatory, proangiogenic, immunomodulatory, and anti-scarring effects that have been demonstrated for ADSCs, which effects on wound healing, soft-tissue restoration and scar remodelling. Nanofat firstly introduced by Tonnard in 2013, is an ultra-purified adipose tissue-derived product that is devoid of mature adipocytes but rich in ADSCs and with regenerative properties.

NCT ID: NCT05396261 Completed - Vaginitis Clinical Trials

a Flexible Wound Dressing for the Management of Genital Skin Conditions

Start date: January 31, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to determine the efficacy of 7-0940 in the management of genital skin conditions in female patients