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Clinical Trial Summary

This is a single arm study to evaluate the efficacy and safety of CD123-targeted CAR-T cells therapy for patients with relapsed/refractory Acute Myeloid Leukemia.


Clinical Trial Description

There are limited options for treatment of relapse/refractory Acute Myeloid Leukemia. CD123 is expressed on most myeloid leukemia cells so it is an ideal target for CAR-T. Some researches have revealed that CD123 is a marker of leukemia stem cells, which indicates that the eradication of CD123 cells may prevent relapse of leukemia. In this study, investigators will evaluate the safety and efficacy of CAR-T targeting CD123 in patients with relapsed/refractory Acute Myeloid Leukemia. The primary goal is safety and efficiency assessment, including adverse events and disease status after treatment. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04272125
Study type Interventional
Source Chongqing Precision Biotech Co., Ltd
Contact Zhi Yang, PhD
Phone 86-13206140093
Email yangzhi@precision-biotech.com
Status Recruiting
Phase Phase 1/Phase 2
Start date December 1, 2019
Completion date July 1, 2024

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